Journal article
Switchable Photoacoustic Imaging of Glutathione Using MnO 2 Nanotubes for Cancer Diagnosis
ACS applied materials & interfaces, Vol.10(51), pp.44231-44239
12/26/2018
PMID: 30499652
Abstract
Glutathione is overexpressed in tumor cells and regulates cancer growth, metastasis, and drug resistance. Therefore, detecting glutathione levels may greatly facilitate cancer diagnosis and treatment response monitoring. Photoacoustic (PA) imaging is a noninvasive modality for high-sensitivity, high-resolution, deep-tissue optical imaging. Switchable PA probes that offer signal on/off responses to tumor targets would further improve the detection sensitivity and signal-to-noise ratio of PA imaging. Here, we explore the use of MnO
nanotubes as a switchable and biodegradable PA probe for dynamic imaging of glutathione in cancer. Glutathione reduces black MnO
nanotubes into colorless Mn
ions, leading to decreased and signal off PA amplitude. In phantoms, we observed a linear response of reduced PA signals of MnO
nanotubes to increased glutathione concentrations. Using melanoma as the disease model, we demonstrated that MnO
nanotube-based PA imaging of glutathione successfully distinguished B16F10 melanoma cells from BEAS-2B normal cells and discriminated B16F10 tumors from healthy skin tissues. Our results showed that MnO
nanotubes are a potent switchable and biodegradable PA probe for glutathione imaging in cancer diagnosis.
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Details
- Title
- Switchable Photoacoustic Imaging of Glutathione Using MnO 2 Nanotubes for Cancer Diagnosis
- Creators
- Chang Liu - University at Buffalo, State University of New YorkDepeng Wang - University at Buffalo, State University of New YorkYe Zhan - University at Buffalo, State University of New YorkLingyue Yan - University at Buffalo, State University of New YorkQian Lu - Washington State UniversityMichael Yu Zarng Chang - University at Buffalo, State University of New YorkJingwen Luo - City University of Hong KongLidai Wang - City University of Hong KongDan Du - Washington State UniversityYuehe Lin - Washington State UniversityJun Xia - University at Buffalo, State University of New YorkYun Wu - University at Buffalo, State University of New York
- Publication Details
- ACS applied materials & interfaces, Vol.10(51), pp.44231-44239
- Academic Unit
- School of Mechanical and Materials Engineering
- Identifiers
- 99901227850701842
- Language
- English
- Resource Type
- Journal article