Journal article
Synthesis and Evaluation of Phosphorodithioate-Based Hydrogen Sulfide Donors
Molecular bioSystems, Vol.9(10), pp.2430-2434
10/2013
Handle:
https://hdl.handle.net/2376/116866
PMCID: PMC3789624
PMID: 23917226
Abstract
A series of
O
-aryl- and alkyl-substituted phosphorodithioates were designed and synthesized as hydrogen sulfide (H
2
S) donors. H
2
S released capability of these compounds was evaluated by fluorescence methods.
O
-aryl substituted donors showed slow and sustained H
2
S release while
O
-alkylated compounds showed very weak H
2
S release capability. We also evaluated donors’ protective effects against hydrogen peroxide (H
2
O
2
)-induced oxidative damage in myocytes and donors’ toxicity toward B16BL6 mouse melanoma cells.
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Details
- Title
- Synthesis and Evaluation of Phosphorodithioate-Based Hydrogen Sulfide Donors
- Creators
- Chung-Min Park - Department of Chemistry, Washington State University, Pullman, WA 99164, United States. Fax: +1-509-335-8867; Tel: +1-509-335-6073Yu Zhao - Department of Chemistry, Washington State University, Pullman, WA 99164, United States. Fax: +1-509-335-8867; Tel: +1-509-335-6073Zhaohui Zhu - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164Armando Pacheco - Department of Chemistry, Washington State University, Pullman, WA 99164, United States. Fax: +1-509-335-8867; Tel: +1-509-335-6073Bo Peng - Department of Chemistry, Washington State University, Pullman, WA 99164, United States. Fax: +1-509-335-8867; Tel: +1-509-335-6073Nelmi O Devarie-Baez - Department of Chemistry, Washington State University, Pullman, WA 99164, United States. Fax: +1-509-335-8867; Tel: +1-509-335-6073Powell Bagdon - Department of Chemistry, Washington State University, Pullman, WA 99164, United States. Fax: +1-509-335-8867; Tel: +1-509-335-6073Hui Zhang - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164Ming Xian - Department of Chemistry, Washington State University, Pullman, WA 99164, United States. Fax: +1-509-335-8867; Tel: +1-509-335-6073
- Publication Details
- Molecular bioSystems, Vol.9(10), pp.2430-2434
- Academic Unit
- Chemistry, Department of; Pharmaceutical Sciences, Department of
- Identifiers
- 99900547861301842
- Language
- English
- Resource Type
- Journal article