Journal article
Synthesis and characterization of tricalcium phosphate with Zn and Mg based dopants
Journal of materials science. Materials in medicine, Vol.19(7), pp.2669-2677
07/2008
Handle:
https://hdl.handle.net/2376/105791
PMID: 18270806
Abstract
The purpose of this study is to prepare tricalcium phosphate (TCP) ceramic by dual dopants of magnesium (Mg) and zinc (Zn), and investigate the influence of dopants on the physical, mechanical and biological properties of TCP. TCP were synthesized with 1 wt% Mg, 0.3 wt% Zn and dual dopants using the precipitation process. Phase composition and microstructures were characterized. Mechanical properties and dissolution behavior in vitro were investigated. Human osteoblast cell culture was used to determine the influence of dopants on cell-materials interactions. XRD analysis indicated that Mg delayed phase transformation from β to α-TCP and pure β-TCP phase was obtained for Mg-doped TCP after sintered at 1250°C. Addition of Mg improved densification behavior of TCP. Compression strength also increased from 24.0 MPa to 77.2 MPa after doping with Mg and Zn. Furthermore, Mg additive reduced the solubility of TCP in vitro. Osteoblast culture studies indicated that the presence of Mg stabilized the cell-material interface and thus improved cell attachment and growth. Zn-doped TCP exhibited good bioactivity, which enhanced cell differentiation and alkaline phosphatase (ALP) expression. The highest cell proliferation and ALP expression were found on dual Mg and Zn doped TCP. The results indicate that Mg and Zn dopants play a significant role towards improving mechanical properties and cell-materials interactions of TCP. This work also demonstrates the potential for dual Mg and Zn doped TCP to be used in orthopedics and dentistry, which displays high mechanical strength, low resorption and improved cell-material interaction.
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Details
- Title
- Synthesis and characterization of tricalcium phosphate with Zn and Mg based dopants
- Creators
- Weichang Xue - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering Washington State University Pullman WA USAKelli Dahlquist - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering Washington State University Pullman WA USAAshis Banerjee - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering Washington State University Pullman WA USAAmit Bandyopadhyay - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering Washington State University Pullman WA USASusmita Bose - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering Washington State University Pullman WA USA
- Publication Details
- Journal of materials science. Materials in medicine, Vol.19(7), pp.2669-2677
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Springer US; Boston
- Identifiers
- 99900547274701842
- Language
- English
- Resource Type
- Journal article