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Synthesis and cytotoxicities of mannose conjugated S-nitroso-N-acetylpenicillamine (SNAP)
Journal article   Peer reviewed

Synthesis and cytotoxicities of mannose conjugated S-nitroso-N-acetylpenicillamine (SNAP)

Xuejun Wu, Xiaoping Tang, Ming Xian, Paul G Brauschweiger and Peng George Wang
Bioorganic & medicinal chemistry, Vol.10(7), pp.2303-2307
07/2002
DOI: https://doi.org/10.1016/S0968-0896(02)00064-0
Handle:
https://hdl.handle.net/2376/116620
PMID: 11983528

Abstract

Magnetic Resonance Spectroscopy Humans Mass Spectrometry S-Nitroso-N-Acetylpenicillamine - chemistry Tumor Cells, Cultured Nitric Oxide - analysis S-Nitroso-N-Acetylpenicillamine - pharmacology Drug Screening Assays, Antitumor Mannose - chemistry S-Nitroso-N-Acetylpenicillamine - chemical synthesis
A series of mannose conjugated S-nitroso-N-acetylpenicillamines (SNAPs) has been synthesized, and their cytotoxicities were assessed for DU 145 human prostate cancer cells and Hela R cancer cells.

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