Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats

Brendan M Walker; Eric P Zorrilla; George F Koob

doi:10.1111/j.1369-1600.2010.00226.x

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Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats

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Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats

Brendan M Walker, Eric P Zorrilla and George F Koob

Addiction biology, Vol.16(1), pp.116-119

01/2011

DOI: https://doi.org/10.1111/j.1369-1600.2010.00226.x

Handle:

https://hdl.handle.net/2376/113189

PMCID: PMC2988980

PMID: 20579007

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https://doi.org/10.1111/j.1369-1600.2010.00226.xView

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Abstract

Naltrexone - analogs & derivatives

Receptors, Opioid, kappa - antagonists & inhibitors

Ethanol - toxicity

Rats, Wistar

Administration, Inhalation

Rats

Dynorphins - physiology

Male

Dose-Response Relationship, Drug

Receptors, Opioid, kappa - physiology

Naltrexone - pharmacology

Self Administration

Animals

Alcohol Deterrents - pharmacology

Injections, Subcutaneous

Narcotic Antagonists - pharmacology

Alcoholism - physiopathology

Substance Withdrawal Syndrome - physiopathology

Premedication

Altered dynorphin opioid peptide systems contribute to increased ethanol self-administration during withdrawal following chronic alcohol exposure. We previously identified that the κ-opioid receptor antagonist nor-binaltorphimine (nor-BNI) selectively reduced ethanol self-administration in dependent animals. The purpose of this study was twofold: (1) determine whether peripherally administered nor-BNI could reduce dependence-induced ethanol self-administration and (2) confirm the selective κ-opioid effects of nor-BNI by administering it 24 hours prior to ethanol self-administration sessions occurring during acute withdrawal. Nor-BNI decreased ethanol self-administration in ethanol-dependent animals, with no effect in nondependent animals. Thus, the κ-opioid/dynorphin system is a viable pharmacotherapeutic target for the treatment of alcoholism.

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Title: Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
Creators: Brendan M Walker - The Scripps Research Institute, La Jolla, CA, USA. b_walker@wsu.edu
Eric P Zorrilla
George F Koob
Publication Details: Addiction biology, Vol.16(1), pp.116-119
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: United States
Grant note: F32 AA014723 / NIAAA NIH HHS F32 AA014723-01 / NIAAA NIH HHS F32 AA014723-03 / NIAAA NIH HHS R01 AA012602-10 / NIAAA NIH HHS R37 AA008459 / NIAAA NIH HHS R37 AA008459-13 / NIAAA NIH HHS R01 AA008459 / NIAAA NIH HHS AA014723 / NIAAA NIH HHS R01 AA008459-21 / NIAAA NIH HHS AA012602 / NIAAA NIH HHS F32 AA014723-02 / NIAAA NIH HHS AA08459 / NIAAA NIH HHS R01 AA012602 / NIAAA NIH HHS
Identifiers: 99900547540501842
Language: English
Resource Type: Journal article