Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence

Brendan M Walker; Glenn R Valdez; Jay P McLaughlin; Georgy Bakalkin

doi:10.1016/j.alcohol.2011.10.006

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Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence

Journal article

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Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence

Brendan M Walker, Glenn R Valdez, Jay P McLaughlin and Georgy Bakalkin

Alcohol (Fayetteville, N.Y.), Vol.46(4), pp.359-370

06/2012

DOI: https://doi.org/10.1016/j.alcohol.2011.10.006

Handle:

https://hdl.handle.net/2376/104202

PMCID: PMC3396024

PMID: 22459870

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Abstract

Self-administration

Impulsivity

Orbitofrontal cortex

Decision making

Withdrawal

Kappa opioid receptor

Nor-binaltorphimine (nor-BNI)

Opioid

Alcohol

Depression

Central nucleus of the amygdala

Prefrontal cortex

Stress

Nucleus accumbens

Place preference

Dependence

Dynorphin

Anxiety

Negative reinforcement

Cognitive dysfunction

Extended amygdala

Negative affect

This review represents the focus of a symposium that was presented at the “Alcoholism and Stress: A Framework for Future Treatment Strategies” conference in Volterra, Italy on May 3–6, 2011 and organized/chaired by Dr. Brendan M. Walker. The primary goal of the symposium was to evaluate and disseminate contemporary findings regarding the emerging role of kappa-opioid receptors (KORs) and their endogenous ligands dynorphins (DYNs) in the regulation of escalated alcohol consumption, negative affect and cognitive dysfunction associated with alcohol dependence, as well as DYN/KOR mediation of the effects of chronic stress on alcohol reward and seeking behaviors. Dr. Glenn Valdez described a role for KORs in the anxiogenic effects of alcohol withdrawal. Dr. Jay McLaughlin focused on the role of KORs in repeated stress-induced potentiation of alcohol reward and increased alcohol consumption. Dr. Brendan Walker presented data characterizing the effects of KOR antagonism within the extended amygdala on withdrawal-induced escalation of alcohol self-administration in dependent animals. Dr. Georgy Bakalkin concluded with data indicative of altered DYNs and KORs in the prefrontal cortex of alcohol dependent humans that could underlie diminished cognitive performance. Collectively, the data presented within this symposium identified the multifaceted contribution of KORs to the characteristics of acute and chronic alcohol-induced behavioral dysregulation and provided a foundation for the development of pharmacotherapeutic strategies to treat certain aspects of alcohol use disorders.

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Title: Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence
Creators: Brendan M Walker - Laboratory of Alcoholism and Addictions Neuroscience, Department of Psychology and Graduate Program in Neuroscience, Alcohol and Drug Abuse Research Program, Translational Addiction Research Center, Washington State University, Pullman, WA, USA
Glenn R Valdez - Department of Psychology, Grand Valley State University, Allendale, MI, USA
Jay P McLaughlin - Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA
Georgy Bakalkin - Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
Publication Details: Alcohol (Fayetteville, N.Y.), Vol.46(4), pp.359-370
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Elsevier Inc
Identifiers: 99900546642301842
Language: English
Resource Type: Journal article