Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles

Benjamin B Kasten; Tiancheng Liu; Jessie R Nedrow-Byers; Paul D Benny; Clifford E Berkman

doi:10.1016/j.bmcl.2012.11.015

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Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles

Journal article

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Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles

Benjamin B Kasten, Tiancheng Liu, Jessie R Nedrow-Byers, Paul D Benny and Clifford E Berkman

Bioorganic & medicinal chemistry letters, Vol.23(2), pp.565-568

01/15/2013

DOI: https://doi.org/10.1016/j.bmcl.2012.11.015

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https://hdl.handle.net/2376/107083

PMCID: PMC3534887

PMID: 23232055

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Abstract

streptavidin

prostate cancer

gold nanoparticles

biotin

prostate-specific membrane antigen

Prostate-specific membrane antigen (PSMA) is a notable biomarker for diagnostic and therapeutic applications in prostate cancer. Gold nanoparticles (AuNPs) provide an attractive nanomaterial platform for combining a variety of targeting, imaging, and cytotoxic agents into a unified device for biomedical research. In this study, we present the generation and evaluation of the first AuNP system functionalized with a small molecule phosphoramidate peptidomimetic inhibitor for the targeted delivery to PSMA-expressing prostate cancer cells. The general approach involved the conjugation of streptavidin-coated AuNPs with a biotin-linked PSMA inhibitor (CTT54) to generate PSMA-targeted AuNPs. In vitro evaluations of these targeted AuNPs were conducted to determine PSMA-mediated and time-dependent binding to PSMA-positive LNCaP cells. The PSMA-targeted AuNPs exhibited significantly higher and selective binding to LNCaP cells compared to control non-targeted AuNPs, thus demonstrating the feasibility of this approach.

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Title: Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles
Creators: Benjamin B Kasten - Department of Chemistry, Washington State University, Pullman, WA 99164-4630, USA
Tiancheng Liu - Department of Chemistry, Washington State University, Pullman, WA 99164-4630, USA
Jessie R Nedrow-Byers - Department of Chemistry, Washington State University, Pullman, WA 99164-4630, USA
Paul D Benny - Department of Chemistry, Washington State University, Pullman, WA 99164-4630, USA
Clifford E Berkman - Department of Chemistry, Washington State University, Pullman, WA 99164-4630, USA
Publication Details: Bioorganic & medicinal chemistry letters, Vol.23(2), pp.565-568
Academic Unit: Chemistry, Department of
Identifiers: 99900546959901842
Language: English
Resource Type: Journal article