Telomere dynamics in macaques and humans

Jeffrey P Gardner; Masayuki Kimura; Weihang Chai; Jameel F Durrani; Levon Tchakmakjian; Xiaojian Cao; Xiaobin Lu; Guanghui Li; Athanasios P Peppas; Joan Skurnick; Woodring E Wright; Jerry W Shay; Abraham Aviv

doi:10.1093/gerona/62.4.367

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Telomere dynamics in macaques and humans

Journal article

Open access

Peer reviewed

Telomere dynamics in macaques and humans

Jeffrey P Gardner, Masayuki Kimura, Weihang Chai, Jameel F Durrani, Levon Tchakmakjian, Xiaojian Cao, Xiaobin Lu, Guanghui Li, Athanasios P Peppas, Joan Skurnick, …

The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.62(4), pp.367-374

04/2007

DOI: https://doi.org/10.1093/gerona/62.4.367

Handle:

https://hdl.handle.net/2376/112648

PMID: 17452729

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Abstract

Humans

Middle Aged

Male

Reverse Transcriptase Polymerase Chain Reaction

Macaca fascicularis - genetics

Tissue Distribution

Animals

Aging - physiology

Polymorphism, Restriction Fragment Length

Macaca fascicularis - metabolism

Female

Telomerase - metabolism

Telomere - physiology

Aged

In humans, telomere length in proliferating tissues shortens with age--a process accelerated with age-related diseases. Thus, telomere length and attrition with age in the nonhuman primate may serve as a useful paradigm for understanding telomere biology in humans. We examined telomere parameters in tissues of young and old Macaca fascicularis and compared them with several tissues from humans. Macaque telomeres were variable in length and exhibited partial synchrony (equivalence) within animals. They were longer than humans, partially because of longer subtelomeric segments. As skeletal muscle telomere length was unchanged with age, we used it as an internal reference to offset interanimal variation in telomere length. We identified age-dependent telomere attrition in lung, pancreas, skin, and thyroid. Similar to humans, telomerase activity was detected in spleen, thymus, digestive tract, and gonads. We conclude that factors that modify telomere attrition and aging in humans may also operate in the macaque.

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Title: Telomere dynamics in macaques and humans
Creators: Jeffrey P Gardner - The Center of Human Development and Aging, Cell Biology and Molecular Medicine, Department of Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA. gardner@umdnj.edu
Masayuki Kimura
Weihang Chai
Jameel F Durrani
Levon Tchakmakjian
Xiaojian Cao
Xiaobin Lu
Guanghui Li
Athanasios P Peppas
Joan Skurnick
Woodring E Wright
Jerry W Shay
Abraham Aviv
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.62(4), pp.367-374
Academic Unit: UNKNOWN
Publisher: United States
Grant note: R21 AG041375 / NIA NIH HHS F32 GM067522 / NIGMS NIH HHS R15 CA132090 / NCI NIH HHS CA75907 / NCI NIH HHS AG020132 / NIA NIH HHS AG021593 / NIA NIH HHS R15 GM099008 / NIGMS NIH HHS
Identifiers: 99900547712801842
Language: English
Resource Type: Journal article