Telomere replication: poised but puzzling

Shilpa Sampathi; Weihang Chai

doi:10.1111/j.1582-4934.2010.01220.x

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Telomere replication: poised but puzzling

Journal article

Open access

Telomere replication: poised but puzzling

Shilpa Sampathi and Weihang Chai

Journal of cellular and molecular medicine, Vol.15(1), pp.3-13

01/2011

DOI: https://doi.org/10.1111/j.1582-4934.2010.01220.x

Handle:

https://hdl.handle.net/2376/108615

PMCID: PMC3076028

PMID: 21122064

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https://doi.org/10.1111/j.1582-4934.2010.01220.xView

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Abstract

shelterin

C-strand fill-in

Reviews

telomerase

G-quadruplex

telomere replication

cancer

Faithful replication of chromosomes is essential for maintaining genome stability. Telomeres, the chromosomal termini, pose quite a challenge to replication machinery due to the complexity in their structures and sequences. Efficient and complete replication of chromosomes is critical to prevent aberrant telomeres as well as to avoid unnecessary loss of telomere DNA. Compelling evidence supports the emerging picture of synergistic actions between DNA replication proteins and telomere protective components in telomere synthesis. This review discusses the actions of various replication and telomere-specific binding proteins that ensure accurate telomere replication and their roles in telomere maintenance and protection.

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Details

Title: Telomere replication: poised but puzzling
Creators: Shilpa Sampathi
Weihang Chai
Publication Details: Journal of cellular and molecular medicine, Vol.15(1), pp.3-13
Academic Unit: UNKNOWN
Publisher: Blackwell Publishing Ltd; Oxford, UK
Identifiers: 99900547262501842
Language: English
Resource Type: Journal article