Journal article
Temporal parameters of desensitization to intravesical resiniferatoxin in the rat
Physiology & behavior, Vol.56(3), pp.479-485
1994
Handle:
https://hdl.handle.net/2376/113170
PMID: 7972397
Abstract
Four days after implantation of a chronic cannula into the bladder dome, vehicle or the capsaicin-like irritant resiniferatoxin (RTX) was injected into bladders of awake, freely moving female rats 4 times at 60-min intervals for exposure durations of 5, 15, or 45 min, or at intervals of 15, 60, or 120 min for 5-min durations. The 1st RTX injection dose-dependently increased time spent engaged in abdominal licking. Regardless of exposure interval and duration, time spent licking increased to a lesser extent with each subsequent injection, indicating desensitization of sensory afferents. Magnitude and duration of desensitization were dose dependent for all exposure regimens, and there were few differences between groups. Desensitization at 24 hrs was also greater in Ss exposed 4 times compared with Ss exposed once. Thus, magnitude and duration of desensitization to locally administered RTX depend primarily on dose and number of exposures to RTX. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
Metrics
9 Record Views
Details
- Title
- Temporal parameters of desensitization to intravesical resiniferatoxin in the rat
- Creators
- R. M CRAFT - Univ. Arizona health sci. cent., dep. pharmacology, Tucson AZ 85724, United StatesF PORRECA - Univ. Arizona health sci. cent., dep. pharmacology, Tucson AZ 85724, United States
- Publication Details
- Physiology & behavior, Vol.56(3), pp.479-485
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier; Cambridge; New York, NY
- Identifiers
- 99900548483001842
- Language
- English
- Resource Type
- Journal article