Journal article
Testosterone modulation of reproductive indices vs. morphine antinociception in male rats
Life sciences (1973), Vol.79(22), pp.2119-2127
2006
Handle:
https://hdl.handle.net/2376/109969
PMID: 16914166
Abstract
The purpose of this study was to determine whether testosterone (T) concurrently modulates reproductive and nociceptive systems in the adult male. Male Sprague–Dawley rats were orchidectomized, and then 28 days later implanted with capsules containing T or nothing (blanks). After 2, 7, 14 or 28 days' exposure to T-filled or blank capsules, rats were tested for male sexual and nociceptive behaviors in a counter-balanced design. As the duration of T exposure lengthened, the percentage of rats showing male sexual behaviors and the weights of steroid-sensitive organs systematically increased, and latencies to show sexual behaviors decreased. T treatment did not affect basal nociception on either the hotplate or tail withdrawal tests, but significantly increased morphine's antinociceptive potency on the tail withdrawal test — however, this effect was small, and independent of duration of T exposure. Thus, T treatment that altered male sexual behavior and reproductive physiology in a systematic, duration-dependent manner did not similarly alter basal nociception or morphine antinociception. These findings suggest that in adult male rats, although T may modulate both male sexual behaviors and opioid antinociceptive sensitivity, these T effects do not occur in concert.
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Details
- Title
- Testosterone modulation of reproductive indices vs. morphine antinociception in male rats
- Creators
- Jean E Sumner - Departments of Psychology, Washington State University, Pullman, WA 99164-4820, USACatherine Ulibarri - Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99614-6520 USARebecca M Craft - Departments of Psychology, Washington State University, Pullman, WA 99164-4820, USA
- Publication Details
- Life sciences (1973), Vol.79(22), pp.2119-2127
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547164801842
- Language
- English
- Resource Type
- Journal article