Journal article
The Effects of RPM and Recycle on Separation Efficiency in a Clinical Blood Cell Centrifuge
Journal of biomechanical engineering, Vol.109(4), pp.324-329
11/01/1987
Handle:
https://hdl.handle.net/2376/116219
PMID: 3695433
Abstract
A COBE blood cell centrifuge, model 2997 with a single stage channel, was modified to allow computer controlled sampling, and to allow recycle of red blood cells (RBCs) and plasma streams using bovine whole blood. The effects of recycle of the packed RBC and plasma product streams, and of the centrifuge RPM on platelet and white blood cell (WBC) separation efficiencies were quantified using a central composite factorial experimental design. These data were then fit using second order models. Both the model for the WBC separation efficiency and the model for the platelet separation efficiency predict that RPM has the greatest effect on separation efficiency and that RBC and plasma recycle have detrimental effects at moderate to low RPM, but have negligible impact on separation efficiency at high RPM.
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Details
- Title
- The Effects of RPM and Recycle on Separation Efficiency in a Clinical Blood Cell Centrifuge
- Creators
- P. D Drumheller - Chemical Engineering Department, Washington State University, Pullman, WA 99164-2710B. J Van Wie - Chemical Engineering Department, Washington State University, Pullman, WA 99164-2710J. N Petersen - Chemical Engineering Department, Washington State University, Pullman, WA 99164-2710R. J Oxford - Chemical Engineering Department, Washington State University, Pullman, WA 99164-2710G. W Schneider - Spokane & Inland Empire Blood Bank, Spokane, WA 99207
- Publication Details
- Journal of biomechanical engineering, Vol.109(4), pp.324-329
- Academic Unit
- Chemical Engineering and Bioengineering, School of
- Publisher
- ASME
- Identifiers
- 99900547404001842
- Language
- English
- Resource Type
- Journal article