Journal article
The Heparan and Heparin Metabolism Pathway is Involved in Regulation of Fatty Acid Composition
International journal of biological sciences, Vol.7(5), pp.659-663
2011
Handle:
https://hdl.handle.net/2376/106205
PMCID: PMC3107474
PMID: 21647334
Abstract
Six genes involved in the heparan sulfate and heparin metabolism pathway,
DSEL
(dermatan sulfate epimerase-like),
EXTL1
(exostoses (multiple)-like 1),
HS6ST1
(heparan sulfate 6-O-sulfotransferase 1),
HS6ST3
(heparan sulfate 6-O-sulfotransferase 3),
NDST3
(N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3), and
SULT1A1
(sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1), were investigated for their associations with muscle lipid composition using cattle as a model organism. Nineteen single nucleotide polymorphisms (SNPs)/multiple nucleotide length polymorphisms (MNLPs) were identified in five of these six genes. Six of these mutations were then genotyped on 246 Wagyu x Limousin F
2
animals, which were measured for 5 carcass, 6 eating quality and 8 fatty acid composition traits. Association analysis revealed that
DSEL
,
EXTL1
and
HS6ST1
significantly affected two stearoyl-CoA desaturase activity indices, the amount of conjugated linoleic acid (CLA), and the relative amount of saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) in skeletal muscle (P<0.05). In particular,
HS6ST1
joined our previously reported
SCD1
and
UQCRC1
genes to form a three gene network for one of the stearoyl-CoA desaturase activity indices. These results provide evidence that genes involved in heparan sulfate and heparin metabolism are also involved in regulation of lipid metabolism in bovine muscle. Whether the SNPs affected heparan sulfate proteoglycan structure is unknown and warrants further investigation.
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Details
- Title
- The Heparan and Heparin Metabolism Pathway is Involved in Regulation of Fatty Acid Composition
- Creators
- Zhihua Jiang - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USAJennifer J Michal - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USAXiao-Lin Wu - 2. Department of Dairy Science, University of Wisconsin-Madison, Madison, WI 53706-1284, USAZengxiang Pan - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USAMichael D MacNeil - 3. USDA-ARS, Fort Keogh Livestock and Range Research Laboratory, Miles City, MT 59301, USA
- Publication Details
- International journal of biological sciences, Vol.7(5), pp.659-663
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Ivyspring International Publisher; Sydney
- Identifiers
- 99900546718501842
- Language
- English
- Resource Type
- Journal article