Journal article
The Sinus Node Inhibitor UL-FS 49 Lacks Significant Inotropic Effect
Journal of cardiovascular pharmacology, Vol.19(2), pp.264-271
02/1992
Handle:
https://hdl.handle.net/2376/106809
PMID: 1376796
Abstract
SUMMARYUL-FS 49 is a sinus node inhibitor that has been reported to reduce heart rate and may be useful in improving myocardial oxygen supply vs. demand. However, previous studies performed in a variety of preparations have produced mixed results regarding the independent inotropic effect of UL-FS 49. To determine whether UL-FS 49 has an inotropic effect, we measured both steady-state hemodynamic responses and transient hemodynamic responses to random preload and afterload changes, both with and without UL-FS 49. We found that under steady-state conditions, the effect of UL-FS 49 is so small that it would be of doubtful physiologic significancea 3% increase in stroke volume (p = 0.007) and 7% increase in peak positive dP/dt (p = 0.051), in the presence of no statistically significant differences in end-diastolic pressure, end-diastolic volume, peak systolic pressure, end-systolic pressure, or heart rate. The more powerful multiple linear regression modeling of hemodynamic transient sequences resulting from random preload and afterload changes showed that UL-FS 49 is without a statistically significant direct effect on left ventricular function. We conclude that UL-FS 49 has no physiologically important direct effect on left ventricular pump function.
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Details
- Title
- The Sinus Node Inhibitor UL-FS 49 Lacks Significant Inotropic Effect
- Creators
- Zengyi Chen - Cardiology Unit, Department of Medicine, University of Vermont, Burlington, Vermont, U.S.ABryan Slinker
- Publication Details
- Journal of cardiovascular pharmacology, Vol.19(2), pp.264-271
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Lippincott-Raven Publishers
- Identifiers
- 99900546834001842
- Language
- English
- Resource Type
- Journal article