Journal article
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling
Nature cell biology, Vol.4(12), pp.970-975
12/2002
Handle:
https://hdl.handle.net/2376/105173
PMID: 12447388
Abstract
WAVE-1, which is also known as Scar, is a scaffolding protein that directs actin reorganization by relaying signals from the GTPase Rac to the Arp2/3 complex. Although the molecular details of WAVE activation by Rac have been described, the mechanisms by which these signals are terminated remain unknown. Here we have used tandem mass spectrometry to identify previously unknown components of the WAVE signalling network including WRP, a Rac-selective GTPase-activating protein. WRP binds directly to WAVE-1 through its Src homology domain 3 and specifically inhibits Rac function in vivo. Thus, we propose that WRP is a binding partner of WAVE-1 that functions as a signal termination factor for Rac.
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Details
- Title
- The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling
- Creators
- John D Scott - Howard Hughes Medical Institute, Vollum InstituteStephen M Davee - Howard Hughes Medical Institute, Vollum InstituteTony Pawson - Department of Molecular and Medical Genetics, University of TorontoKathleen L Binns - Samuel Lunenfeld Research Institute, Mount Sinai Hospital Department of Molecular and Medical Genetics, University of TorontoScott H Soderling - Howard Hughes Medical Institute, Vollum InstituteGary A Wayman - Vollum InstituteSiew Hwa Ong - Samuel Lunenfeld Research Institute, Mount Sinai Hospital
- Publication Details
- Nature cell biology, Vol.4(12), pp.970-975
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900546897201842
- Language
- English
- Resource Type
- Journal article