The Zinc-Binding Protein Chordc1 Undergoes Complex Diurnal Changes in mRNA Expression During Mouse Brain Development

Jason Gerstner; Charles Landry

doi:10.1007/s11064-006-9271-z

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The Zinc-Binding Protein Chordc1 Undergoes Complex Diurnal Changes in mRNA Expression During Mouse Brain Development

Journal article

Open access

Peer reviewed

The Zinc-Binding Protein Chordc1 Undergoes Complex Diurnal Changes in mRNA Expression During Mouse Brain Development

Jason Gerstner and Charles Landry

Neurochemical research, Vol.32(2), pp.241-250

02/2007

DOI: https://doi.org/10.1007/s11064-006-9271-z

Handle:

https://hdl.handle.net/2376/107537

PMCID: PMC6528676

PMID: 17253150

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https://doi.org/10.1007/s11064-006-9271-zView

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Abstract

Biochemistry, general

p23

Hsp90

Neurology

Neurosciences

Biomedicine

Sleep

RAR1

Circadian

Chp-1

Diurnal changes in Chordc1 mRNA were recently described in mouse hypothalamus. This report shows that Chordc1 mRNA changes rhythmically throughout the entire adult brain with highest expression levels occurring around the dark–light transition. The rhythmic cycling pattern of Chordc1 was retained under various light–dark schedules and analysis of adult whole brain revealed diurnal patterns that were different than young animals (postnatal day (P) 6). Analysis of adult hippocampus, prefrontal cortex and cerebellum confirmed these observations and a comparison between adult and P6 animals using in situ hybridization indicated that Chordc1 underwent coordinated but altered diurnal changes in mRNA abundance during development. Further, a developmental profile of Chordc1 expression beginning at embryonic day 17 revealed a regional distribution of Chordc1 consistent with its adult pattern. These results suggest that Chordc1 mRNA is under complex and widespread transcriptional regulation during development and implicate Chordc1 in circadian and/or homeostatic mechanisms in mammalian brain.

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Title: The Zinc-Binding Protein Chordc1 Undergoes Complex Diurnal Changes in mRNA Expression During Mouse Brain Development
Creators: Jason Gerstner - Neuroscience Training Program and Department of Psychiatry University of Wisconsin-Madison Madison WI 53719 USA
Charles Landry - Department of Psychiatry University of Wisconsin-Madison 6001 Research Park Blvd. Madison WI 53711 USA
Publication Details: Neurochemical research, Vol.32(2), pp.241-250
Academic Unit: Biomedical Sciences, Department of
Publisher: Kluwer Academic Publishers-Plenum Publishers; New York
Identifiers: 99900547012901842
Language: English
Resource Type: Journal article