The acute antinociceptive effect of HBO2 is mediated by a NO–cyclic GMP–PKG–KATP channel pathway in mice

Lindsay P Quock; Yao Zhang; Eunhee Chung; Yusuke Ohgami; Donald Y Shirachi; Raymond M Quock

doi:10.1016/j.brainres.2010.10.079

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The acute antinociceptive effect of HBO2 is mediated by a NO–cyclic GMP–PKG–KATP channel pathway in mice

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The acute antinociceptive effect of HBO2 is mediated by a NO–cyclic GMP–PKG–KATP channel pathway in mice

Lindsay P Quock, Yao Zhang, Eunhee Chung, Yusuke Ohgami, Donald Y Shirachi and Raymond M Quock

Brain research, Vol.1368, pp.102-107

01/12/2011

DOI: https://doi.org/10.1016/j.brainres.2010.10.079

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https://hdl.handle.net/2376/104141

PMCID: PMC3023906

PMID: 20977894

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https://doi.org/10.1016/j.brainres.2010.10.079View

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Abstract

nitric oxide

antinociception

potassium channels

Hyperbaric oxygen

cyclic GMP

protein kinase G

mice

Previous research has found that hyperbaric oxygen (HBO 2 ) produces an acute antinociceptive effect that is dependent on nitric oxide (NO). The present study was undertaken to determine whether HBO 2 -induced acute antinociception might involve a NO–cyclic GMP–protein kinase G–ATP-sensitive potassium (K ATP ) channel pathway. Male NIH Swiss mice were subjected to a 5-min HBO 2 treatment (100% oxygen at 3.5 absolute atmospheres) and antinociception was assessed over the next 6 min still under HBO 2 using the acetic acid abdominal constriction test. Pretreatment with 2-(4-carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3-oxide (carboxy-PTIO, an NO scavenger), 1H-[1,2,4]-oxadiazolo-[4,3-a]quinoxalin-1-one) (a soluble guanylyl cyclase-inhibitor, Rp-8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphorothioate (a protein kinase G-inhibitor) or glibenclamide (an ATP-sensitive potassium channel-inhibitor) all led to antagonism of the HBO 2 -induced acute antinociception in a dose-dependent manner. These findings suggest that HBO 2 -induced acute antinociception might be due to activation of a NO–cyclic GMP–protein kinase G–K ATP channel pathway.

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Title: The acute antinociceptive effect of HBO2 is mediated by a NO–cyclic GMP–PKG–KATP channel pathway in mice
Creators: Lindsay P Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA, USA
Yao Zhang - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA, USA
Eunhee Chung - Institute of Scientific Criminal Investigation, Graduate School of Peace and Security Studies, Chungnam National University, Daejeon, Republic of Korea
Yusuke Ohgami - Department of Scientific Criminal Investigation, Graduate School of Peace and Security Studies, Chungnam National University, Daejeon, Republic of Korea
Donald Y Shirachi - Chico Hyperbaric Center, Chico, CA, USA
Raymond M Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA, USA
Publication Details: Brain research, Vol.1368, pp.102-107
Academic Unit: Psychology, Department of
Identifiers: 99900546826001842
Language: English
Resource Type: Journal article