Journal article
The acute antinociceptive effect of hyperbaric oxygen is not accompanied by an increase in markers of oxidative stress
Life sciences (1973), Vol.98(1), pp.44-48
03/07/2014
Handle:
https://hdl.handle.net/2376/106583
PMCID: PMC3943864
PMID: 24418003
Abstract
Exposure to hyperbaric oxygen (HBO2) causes an antinociceptive response in mice. However, breathing oxygen (O2) at an elevated pressure can potentially cause oxygen toxicity. The aim of this study was to identify the determinants of HBO2 antinociception and the toxicity profile of HBO2.
Male NIH Swiss mice were assessed for acute antinociceptive responsiveness under room air or 100% O2 at 1.0 or 3.5 atmospheres absolute (ATA), using the acetic acid-induced abdominal constriction test. For the oxygen toxicity test, mice were exposed to 3.5 ATA oxygen for 11min, 60min, and 60min daily for 2days (120min) or 60min daily for 4days (240min), then assessed by analyzing the levels of two oxidative stress markers, MDA (malondialdehyde) and protein carbonyl in brain, spinal cord and lung.
Only the combination of 100% O2 and 3.5 ATA caused significant antinociception. The antinociceptive effect of 100% O2 was pressure-dependent up to 3.5 ATA. In the oxygen toxicity test, mice exposed to HBO2 for different time intervals had levels of brain, spinal cord and lung MDA and protein carbonyl that were comparable to that of control animals exposed to room air.
Treatment with 100% O2 evokes a pressure-dependent antinociceptive effect. Since there was no significant increase in levels of the oxidative stress markers in the tested tissues, it is concluded that HBO2 at 3.5 ATA produces antinociception in the absence of oxidative stress in mice.
Metrics
7 Record Views
Details
- Title
- The acute antinociceptive effect of hyperbaric oxygen is not accompanied by an increase in markers of oxidative stress
- Creators
- Shulin Liu - Department of Diving Medicine, Second Military Medical University, Shanghai, ChinaDonald Y Shirachi - Department of Physiology and Pharmacology, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USARaymond M Quock - Department of Psychology, Washington State University, Pullman, WA 99164, USA
- Publication Details
- Life sciences (1973), Vol.98(1), pp.44-48
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547190201842
- Language
- English
- Resource Type
- Journal article