The anterolateral projections of the medial basal hypothalamus affect sleep

Zoltan Peterfi; Gábor B Makara; Ferenc Obál, Jr; James M Krueger

doi:10.1152/ajpregu.90958.2008

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The anterolateral projections of the medial basal hypothalamus affect sleep

Journal article

Open access

Peer reviewed

The anterolateral projections of the medial basal hypothalamus affect sleep

Zoltan Peterfi, Gábor B Makara, Ferenc Obál, Jr and James M Krueger

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.296(4), pp.R1228-1238

04/2009

DOI: https://doi.org/10.1152/ajpregu.90958.2008

Handle:

https://hdl.handle.net/2376/106416

PMCID: PMC2698612

PMID: 19193940

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Abstract

Rats

Drinking

Male

Surgical Instruments

Arcuate Nucleus of Hypothalamus - physiopathology

Electroencephalography

Photoperiod

Preoptic Area - physiopathology

Body Temperature

Circadian Rhythm

Equipment Design

Hypothalamus - physiopathology

Rats, Sprague-Dawley

Behavior, Animal

Neurosurgery - instrumentation

Sleep Deprivation - physiopathology

Animals

Hypothalamus - surgery

Sleep Stages

Sleep, REM

Neural Pathways - physiopathology

The role of the medial basal hypothalamus (MBH) and the anterior hypothalamus/preoptic area (AH/POA) in sleep regulation was investigated using the Halász knife technique to sever MBH anterior and lateral projections in rats. If both lateral and anterior connections of the MBH were cut, rats spent less time in non-rapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS). In contrast, if the lateral connections remained intact, the duration of NREMS and REMS was normal. The diurnal rhythm of NREMS and REMS was altered in all groups except the sham control group. Changes in NREMS or REMS duration were not detected in a group with pituitary stalk lesions. Water consumption was enhanced in three groups of rats, possibly due to the lesion of vasopressin fibers entering the pituitary. EEG delta power during NREMS and brain temperatures (Tbr) were not affected by the cuts during baseline or after sleep deprivation. In response to 4 h of sleep deprivation, only one group, that with the most anterior-to-posterior cuts, failed to increase its NREMS or REMS time during the recovery sleep. After deprivation, Tbr returned to baseline in most of the treatment groups. Collectively, results indicate that the lateral projections of the MBH are important determinants of duration of NREMS and REMS, while more anterior projections are concerned with the diurnal distribution of sleep. Further, the MBH projections involved in sleep regulation are distinct from those involved in EEG delta activity, water intake, and brain temperature.

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Title: The anterolateral projections of the medial basal hypothalamus affect sleep
Creators: Zoltan Peterfi - Department of Veterinary and Comparative Anatomy, Washington State Univesity, Pullman, WA 99164-6520, USA
Gábor B Makara
Ferenc Obál, Jr
James M Krueger
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.296(4), pp.R1228-1238
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: United States
Grant note: NS27250 / NINDS NIH HHS
Identifiers: 99900546799501842
Language: English
Resource Type: Journal article