The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction

Patricia A Hunt; Martha Susiarjo; Carmen Rubio; Terry J Hassold

doi:10.1095/biolreprod.109.077008

Back

The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction

Journal article

Open access

Peer reviewed

The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction

Patricia A Hunt, Martha Susiarjo, Carmen Rubio and Terry J Hassold

Biology of reproduction, Vol.81(5), pp.807-813

11/2009

DOI: https://doi.org/10.1095/biolreprod.109.077008

Handle:

https://hdl.handle.net/2376/110131

PMID: 19458313

Files and links (1)

url

https://doi.org/10.1095/biolreprod.109.077008View

Published (Version of record) Open

Abstract

Benzhydryl Compounds

Species Specificity

Phenols - toxicity

Humans

Male

Environmental Exposure

Endocrine Disruptors - toxicity

Pregnancy

Reproduction - drug effects

Animals

Estrogens, Non-Steroidal - toxicity

Female

Environmental Pollutants - toxicity

Genitalia - drug effects

It is increasingly evident that environmental factors are a veritable Pandora's box from which new concerns and complications continue to emerge. Although previously considered the domain of toxicologists, it is now clear that an understanding of the effects of the environment on reproduction requires a far broader range of expertise and that, at least for endocrine-disrupting chemicals, many of the tenets of classical toxicology need to be revisited. Indeed, because of the wide range of reproductive effects induced by these chemicals, interest among reproductive biologists has grown rapidly: in 2000, the program for the annual Society for the Study of Reproduction meeting included a single minisymposium on the fetal origins of adult disease, one platform session on endocrine disruption, and 23 toxicology poster presentations. In contrast, environmental factors featured prominently at the 2009 meeting, with strong representation in the plenary, minisymposia, platform, and poster sessions. Clearly, a lot has happened in a decade, and environmental issues have become an increasingly important research focus for reproductive biologists. In this review, we summarize some of the inherent difficulties in assessing environmental effects on reproductive performance, focusing on the endocrine disruptor bisphenol A (BPA) to illustrate important emerging concerns. In addition, because the BPA experience serves as a prototype for scientific activism, public education, and advocacy, these issues are also discussed.

Metrics

8 Record Views

Details

Title: The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction
Creators: Patricia A Hunt - School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164-4660, USA. pathunt@wsu.edu
Martha Susiarjo
Carmen Rubio
Terry J Hassold
Publication Details: Biology of reproduction, Vol.81(5), pp.807-813
Academic Unit: Molecular Biosciences, School of
Publisher: United States
Grant note: R01 ES013527 / NIEHS NIH HHS ES013527 / NIEHS NIH HHS HD21341 / NICHD NIH HHS R01 HD021341 / NICHD NIH HHS R37 HD021341 / NICHD NIH HHS
Identifiers: 99900547112001842
Language: English
Resource Type: Journal article