Journal article
The changing nature of the Brucella-containing vacuole
Cellular microbiology, Vol.17(7), pp.951-958
07/2015
Handle:
https://hdl.handle.net/2376/102857
PMCID: PMC4478208
PMID: 25916795
Abstract
Bacteria of the genus Brucella are intracellular vacuolar pathogens of mammals that cause the worldwide zoonosis brucellosis, and reside within phagocytes of infected hosts to promote their survival, persistence and proliferation. These traits are essential to the bacterium's ability to cause disease and have been the subject of much investigation to gain an understanding of Brucella pathogenic mechanisms. Although the endoplasmic reticulum-derived nature of the Brucella replicative niche has been long known, major strides have recently been made in deciphering the molecular mechanisms of its biogenesis, including the identification of bacterial determinants and host cellular pathways involved in this process. Here I will review and discuss the most recent advances in our knowledge of Brucella intracellular pathogenesis, with an emphasis on bacterial exploitation of the host endoplasmic reticulum-associated functions, and how autophagy-related processes contribute to the bacterium's intracellular cycle.
Metrics
7 Record Views
Details
- Title
- The changing nature of the Brucella-containing vacuole
- Creators
- Jean Celli - Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, WA, USA
- Publication Details
- Cellular microbiology, Vol.17(7), pp.951-958
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Publisher
- England
- Grant note
- R21 AI112649 / NIAID NIH HHS AI112649 / NIAID NIH HHS
- Identifiers
- 99900546674501842
- Language
- English
- Resource Type
- Journal article