Journal article
The divergent C. elegans ephrin EFN-4 functions inembryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor
Development (Cambridge), Vol.129(23), pp.5499-5510
12/2002
Handle:
https://hdl.handle.net/2376/104373
PMID: 12403719
Abstract
The C. elegans genome encodes a single Eph receptor tyrosine kinase, VAB-1, which functions in neurons to control epidermal morphogenesis. Four members of the ephrin family of ligands for Eph receptors have been identified in C. elegans. Three ephrins (EFN-1/VAB-2, EFN-2 and EFN-3) have been previously shown to function in VAB-1 signaling. We show that mutations in the gene mab-26 affect the fourth C. elegans ephrin, EFN-4. We show that efn-4 also functions in embryonic morphogenesis, and that it is expressed in the developing nervous system. Interestingly, efn-4 mutations display synergistic interactions with mutations in the VAB-1 receptor and in the EFN-1 ephrin, indicating that EFN-4 may function independently of the VAB-1 Eph receptor in morphogenesis. Mutations in the LAR-like receptor tyrosine phosphatase PTP-3 and in the Semaphorin-2A homolog MAB-20 disrupt embryonic neural morphogenesis. efn-4 mutations synergize with ptp-3 mutations, but not with mab-20 mutations, suggesting that EFN-4 and Semaphorin signaling could function in a common pathway or in opposing pathways in C. elegans embryogenesis.
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Details
- Title
- The divergent C. elegans ephrin EFN-4 functions inembryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor
- Creators
- Ian D Chin-Sang - Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064, USASarah L MoseleyMei DingRobert J HarringtonSean E GeorgeAndrew D Chisholm
- Publication Details
- Development (Cambridge), Vol.129(23), pp.5499-5510
- Publisher
- England
- Grant note
- R01 GM054657 / NIGMS NIH HHS GM54657 / NIGMS NIH HHS
- Identifiers
- 99900546524501842
- Language
- English
- Resource Type
- Journal article