Journal article
The draft genome of the parasitic nematode Trichinella spiralis
Nature genetics, Vol.43(3), pp.228-235
03/2011
Handle:
https://hdl.handle.net/2376/108348
PMCID: PMC3057868
PMID: 21336279
Abstract
Genome-based studies of metazoan evolution are most informative when phylogenetically diverse species are incorporated in the analysis. As such, evolutionary trends within and outside the phylum Nematoda have been less revealing by focusing only on comparisons involving
Caenorhabditis elegans
. Herein, we present a draft of the 64 megabase nuclear genome of
Trichinella spiralis,
containing 15,808 protein coding genes. This parasitic nematode is an extant member of a clade that diverged early in the evolution of the phylum enabling identification of archetypical genes and molecular signatures exclusive to nematodes. Comparative analyses support intrachromosomal rearrangements across the phylum, disproportionate numbers of protein family deaths over births in parasitic vs. a non-parasitic nematode, and a preponderance of gene loss and gain events in nematodes relative to
Drosophila melanogaster
. This sequence and the panphylum characteristics identified herein will advance evolutionary studies and strategies to combat global parasites of humans, food animals and crops.
Metrics
4 Record Views
Details
- Title
- The draft genome of the parasitic nematode Trichinella spiralis
- Creators
- Makedonka Mitreva - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Douglas P Jasmer - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164Dante S Zarlenga - U.S. Department of Agriculture, Animal Parasitic Disease Laboratory, Beltsville, Maryland 20705Zhengyuan Wang - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Sahar Abubucker - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108John Martin - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Christina M Taylor - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Yong Yin - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Lucinda Fulton - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Pat Minx - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Shiaw-Pyng Yang - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Wesley C Warren - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Robert S Fulton - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Veena Bhonagiri - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Xu Zhang - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Kym Hallsworth-Pepin - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Sandra W Clifton - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108James P McCarter - Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108Judith Appleton - James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, New York 14853Elaine R Mardis - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108Richard K Wilson - The Genome Center, Washington University School of Medicine, St. Louis, MO 63108
- Publication Details
- Nature genetics, Vol.43(3), pp.228-235
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Identifiers
- 99900547279201842
- Language
- English
- Resource Type
- Journal article