Journal article
The effect of hyperbaric oxygen on regional brain and spinal cord levels of nitric oxide metabolites in rat
Brain research bulletin, Vol.75(5), pp.668-673
2008
Handle:
https://hdl.handle.net/2376/107444
PMID: 18355644
Abstract
Hyperbaric oxygen (HBO
2) therapy is reported to be beneficial in transient brain ischemia. The present study was conducted to determine the influence of HBO
2 on metabolites of nitric oxide (NO) in brain and spinal cord of rats. Rats were exposed to room air (RA), normobaric air (NBA), normobaric oxygen (NBO
2), hyperbaric air (HBA) or HBO
2, the last two conditions at 2.5
ATA (atmosphere absolute) for 60
min. The results demonstrate that, compared to the NBA control, oxygen alone generally reduced tissue levels of NO
x
− (nitrite plus nitrate). On the other hand, 2.5
ATA alone tended to have a slight, if any, effect on tissue levels of NO
x
−. The combination of oxygen and pressure (i.e., HBO
2) generally led to an increase in tissue levels of NO
x
−. Based on these findings, it is concluded that HBO
2 appears to markedly increase NO function most notably in the corpus striatum, brainstem, cerebellum and spinal cord.
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Details
- Title
- The effect of hyperbaric oxygen on regional brain and spinal cord levels of nitric oxide metabolites in rat
- Creators
- Yusuke Ohgami - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USAEunhee Chung - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USADonald Y Shirachi - Chico Hyperbaric Center, Chico, CA 95926-3509, USARaymond M Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USA
- Publication Details
- Brain research bulletin, Vol.75(5), pp.668-673
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546813201842
- Language
- English
- Resource Type
- Journal article