Journal article
The effects of alprazolam on conditioned place preferences produced by intravenous heroin
Pharmacology, biochemistry and behavior, Vol.75(1), pp.75-80
04/2003
Handle:
https://hdl.handle.net/2376/116857
PMID: 12759115
Abstract
Case studies reveal that opiate addicts often self-medicate with benzodiazepine (BDZ) tranquilizers prior to taking their opiate. Our laboratory has previously utilized the conditioned place preference paradigm to confirm that BDZs can augment the affective response to heroin in laboratory animals. The combination of alprazolam and varying doses of intravenous heroin resulted in a leftward shift of the heroin dose-response curve. The present experiment was devised to extend the previous findings by examining the ability of varying alprazolam doses (0.125, 0.25, or 0.5 mg/kg ip) to potentiate the reward of a single challenge dose of heroin (0.025 mg/kg iv). The results demonstrate that a nonrewarding dose of alprazolam (0.125 mg/kg) and intravenous heroin can interact to produce reliable place preferences. The data thereby support prior work from our laboratory regarding the synergistic actions of BDZs and opiates.
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Details
- Title
- The effects of alprazolam on conditioned place preferences produced by intravenous heroin
- Creators
- Brendan M Walker - Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, USAAaron Ettenberg
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.75(1), pp.75-80
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- F31 DA006019-01A1 / NIDA NIH HHS F31 DA006019-02 / NIDA NIH HHS F31 DA006019 / NIDA NIH HHS DA 06019 / NIDA NIH HHS DA 05041 / NIDA NIH HHS
- Identifiers
- 99900548169901842
- Language
- English
- Resource Type
- Journal article