Journal article
The efficacy of δ-opioid receptor-selective drugs
Life sciences (1973), Vol.62(17), pp.1531-1536
1998
Handle:
https://hdl.handle.net/2376/105753
PMID: 9585131
Abstract
δ-Opioid receptor-selective drugs may provide an alternative to μ-opioid-selective drugs currently used for the relief of pain. To develop improved δ-opioid receptor-selective drugs, better measures of drug activity are necessary. In this review we suggest that efficacy calculations provide a superior measure of drug activity as compared to dissociation constants and drug potencies in functional assays. Efficacy, as discussed in this review, is defined as a quantitative measurement of the ability of a drug to stimulate second messenger systems or measurable functional responses in cells or tissues under standard conditions. Efficacy values will allow medicinal chemists to understand the contributions of both the coupling efficiency and dissociation constant to drug potencies in the development of new δ-opioid receptor-selective drugs.
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Details
- Title
- The efficacy of δ-opioid receptor-selective drugs
- Creators
- T.H Burkey - Departments of Pharmacology and Chemistry, University of Arizona, Tucson, AZ 86724, USAF.J Ehlert - University of California at Irvine, College of Medicine, Irvine, CA 92717 USAY HosohataR.M Quock - University of Illinois College of Medicine at Rockford, Rockford, IL 61107 USAS CowellK HosohataE VargaD StropovaX LiC SlateH Nagase - Toray Industries Inc., Kamakura 248, JapanF PorrecaV.J HrubyW.R RoeskeH.I Yamamura
- Publication Details
- Life sciences (1973), Vol.62(17), pp.1531-1536
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547058401842
- Language
- English
- Resource Type
- Journal article