Journal article
The genetic prehistory of the New World Arctic
Science (American Association for the Advancement of Science), Vol.345(6200), pp.1255832-1020
08/29/2014
Handle:
https://hdl.handle.net/2376/107016
PMID: 25170159
Abstract
The New World Arctic, the last region of the Americas to be populated by humans, has a relatively well-researched archaeology, but an understanding of its genetic history is lacking. We present genome-wide sequence data from ancient and present-day humans from Greenland, Arctic Canada, Alaska, Aleutian Islands, and Siberia. We show that Paleo-Eskimos (~3000 BCE to 1300 CE) represent a migration pulse into the Americas independent of both Native American and Inuit expansions. Furthermore, the genetic continuity characterizing the Paleo-Eskimo period was interrupted by the arrival of a new population, representing the ancestors of present-day Inuit, with evidence of past gene flow between these lineages. Despite periodic abandonment of major Arctic regions, a single Paleo-Eskimo metapopulation likely survived in near-isolation for more than 4000 years, only to vanish around 700 years ago.
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Details
- Title
- The genetic prehistory of the New World Arctic
- Creators
- Maanasa Raghavan - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkMichael DeGiorgio - Department of Biology, Pennsylvania State University, 502 Wartik Laboratory, University Park, PA 16802, USAAnders Albrechtsen - Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen, DenmarkIda Moltke - Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, 2200 Copenhagen, Denmark. Department of Human Genetics, University of Chicago, Chicago, IL 60637, USAPontus Skoglund - Department of Evolutionary Biology, Uppsala University, Norbyvägen 18D, 75236 Uppsala, Sweden. Department of Genetics, Harvard Medical School, Boston, MA 02115, USAThorfinn S Korneliussen - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkBjarne Grønnow - Arctic Centre at the Ethnographic Collections (SILA), National Museum of Denmark, Frederiksholms Kanal 12, 1220 Copenhagen, DenmarkMartin Appelt - Arctic Centre at the Ethnographic Collections (SILA), National Museum of Denmark, Frederiksholms Kanal 12, 1220 Copenhagen, DenmarkHans Christian Gulløv - Arctic Centre at the Ethnographic Collections (SILA), National Museum of Denmark, Frederiksholms Kanal 12, 1220 Copenhagen, DenmarkT Max Friesen - Department of Anthropology, University of Toronto, Toronto, Ontario M5S 2S2, CanadaWilliam Fitzhugh - Arctic Studies Center, Post Office Box 37012, Department of Anthropology, MRC 112, National Museum of Natural History, Smithsonian Institution, Washington, DC 20013-7012, USAHelena Malmström - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark. Department of Evolutionary Biology, Uppsala University, Norbyvägen 18D, 75236 Uppsala, SwedenSimon Rasmussen - Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, 2800 Kongens Lyngby, DenmarkJesper Olsen - AMS 14C Dating Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C, DenmarkLinea Melchior - Anthropological Laboratory, Institute of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Frederik V's Vej 11, 2100 Copenhagen, DenmarkBenjamin T Fuller - Department of Earth System Science, University of California, Irvine, CA 92697, USASimon M Fahrni - Department of Earth System Science, University of California, Irvine, CA 92697, USAThomas Stafford, Jr - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark. AMS 14C Dating Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C, DenmarkVaughan Grimes - Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada. Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, GermanyM A Priscilla Renouf - Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, CanadaJerome Cybulski - Canadian Museum of History, 100 Rue Laurier, Gatineau, Quebec K1A 0M8, Canada. Department of Anthropology, University of Western Ontario, 1151 Richmond Street North, London N6A 5C2, CanadaNiels Lynnerup - Anthropological Laboratory, Institute of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Frederik V's Vej 11, 2100 Copenhagen, DenmarkMarta Mirazon Lahr - Leverhulme Centre for Human Evolutionary Studies, Department of Archaeology and Anthropology, University of Cambridge, Cambridge CB2 1QH, UKKate Britton - Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany. Department of Archaeology, University of Aberdeen, St. Mary's Building, Elphinstone Road, Aberdeen AB24 3UF, Scotland, UKRick Knecht - Department of Archaeology, University of Aberdeen, St. Mary's Building, Elphinstone Road, Aberdeen AB24 3UF, Scotland, UKJette Arneborg - National Museum of Denmark, Frederiksholms kanal 12, 1220 Copenhagen, Denmark. School of Geosciences, University of Edinburgh, Edinburgh EH8 9XP, UKMait Metspalu - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia. Department of Evolutionary Biology, University of Tartu, Tartu 51010, EstoniaOmar E Cornejo - Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USA. School of Biological Sciences, Washington State University, Post Office Box 644236, Pullman, WA 99164, USAAnna-Sapfo Malaspinas - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkYong Wang - Department of Integrative Biology, University of California, Berkeley, CA 94720, USA. Ancestry.com DNA LLC, San Francisco, CA 94107, USAMorten Rasmussen - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkVibha Raghavan - Informatics and Bio-computing, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, Ontario, M5G 0A3, CanadaThomas V O Hansen - Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, DenmarkElza Khusnutdinova - Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia. Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Bashkortostan 450074, RussiaTracey Pierre - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkKirill Dneprovsky - State Museum for Oriental Art, 12a, Nikitsky Boulevard, Moscow 119019, RussiaClaus Andreasen - Greenland National Museum and Archives, Post Office Box 145, 3900 Nuuk, GreenlandHans Lange - Greenland National Museum and Archives, Post Office Box 145, 3900 Nuuk, GreenlandM Geoffrey Hayes - Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Department of Anthropology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60208, USA. Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USAJoan Coltrain - Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USAVictor A Spitsyn - Research Centre for Medical Genetics of Russian Academy of Medical Sciences, 1 Moskvorechie, Moscow 115478, RussiaAnders Götherström - Department of Archaeology and Classical Studies, Stockholm University, Stockholm, SwedenLudovic Orlando - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkToomas Kivisild - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia. Department of Archaeology and Anthropology, University of Cambridge, Cambridge CB2 1QH, UKRichard Villems - Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia. Department of Evolutionary Biology, University of Tartu, Tartu 51010, EstoniaMichael H Crawford - Laboratory of Biological Anthropology, University of Kansas, Lawrence, KS 66045, USAFinn C Nielsen - Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, DenmarkJørgen Dissing - Anthropological Laboratory, Institute of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Frederik V's Vej 11, 2100 Copenhagen, DenmarkJan Heinemeier - AMS 14C Dating Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000 Aarhus C, DenmarkMorten Meldgaard - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkCarlos Bustamante - Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305, USADennis H O'Rourke - Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USAMattias Jakobsson - Department of Evolutionary Biology, Uppsala University, Norbyvägen 18D, 75236 Uppsala, SwedenM Thomas P Gilbert - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, DenmarkRasmus Nielsen - Department of Integrative Biology, University of California, Berkeley, CA 94720, USAEske Willerslev - Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark. ewillerslev@snm.ku.dk
- Publication Details
- Science (American Association for the Advancement of Science), Vol.345(6200), pp.1255832-1020
- Academic Unit
- Biological Sciences, School of
- Publisher
- United States
- Identifiers
- 99900546779001842
- Language
- English
- Resource Type
- Journal article