Journal article
The glypican 3-hosted murine mir717 gene: sequence conservation, seed region polymorphisms and putative targets
International journal of biological sciences, Vol.6(7), pp.769-772
12/02/2010
Handle:
https://hdl.handle.net/2376/115961
PMCID: PMC2999852
PMID: 21152117
Abstract
Mir717 (mmu-mir-717) was first reported in mouse and resides in the intron 3 of glypican 3 (Gpc3) gene. Our present study revealed that this microRNA (miRNA) gene is conserved among 26 mammalian species and harbors polymorphic sites within the mature seed region in mice. Our finding represents a rare four layer genomic overlap consisting of growth associated quantitative trait locus (QTL), body mass associated Gpc3 gene, highly conserved miRNA gene and mature miRNA seed single nucleotide polymorphism (SNP) identified in the lean mouse strain 129/Sv. Additionally, genes potentially targeted by Mir717 include 91 genes associated with obesity and related phenotypes in mammals. Our analysis provides a basis for further experiments to causally connect the identified SNP and Mir717 gene itself to obesity regulation. Furthermore, our bioinformatics analysis now enables functional annotation of Mir717 orthologs in other species, thus determining the effect of its target genes on fat-related traits.
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Details
- Title
- The glypican 3-hosted murine mir717 gene: sequence conservation, seed region polymorphisms and putative targets
- Creators
- Tanja Kunej - Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI- 1230 Domzale, Slovenia. jiangz@wsu.eduDasa Jevsinek SkokSimon HorvatPeter DovcZhihua Jiang
- Publication Details
- International journal of biological sciences, Vol.6(7), pp.769-772
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Australia
- Identifiers
- 99900547848001842
- Language
- English
- Resource Type
- Journal article