The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals

Tanushree Ganguly; Benjamin B Kasten; Dejan-Krešimir Bučar; Leonard R MacGillivray; Clifford E Berkman; Paul D Benny

doi:10.1039/c1cc15451f

Back

The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals

Journal article

Open access

The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals

Tanushree Ganguly, Benjamin B Kasten, Dejan-Krešimir Bučar, Leonard R MacGillivray, Clifford E Berkman and Paul D Benny

Chemical communications (Cambridge, England), Vol.47(48), pp.12846-12848

12/28/2011

DOI: https://doi.org/10.1039/c1cc15451f

Handle:

https://hdl.handle.net/2376/110896

PMCID: PMC3236597

PMID: 22044929

Files and links (1)

url

https://doi.org/10.1039/c1cc15451fView

Published (Version of record) Open

Abstract

Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO) 3 (M = Re, 99m Tc) based radiopharmaceuticals. Both ‘click, then chelate’ and ‘prelabel, then click’ synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.

Metrics

12 Record Views

Details

Title: The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, 99mTc) radiopharmaceuticals
Creators: Tanushree Ganguly - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858
Benjamin B Kasten - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858
Dejan-Krešimir Bučar - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Fax: 319-335-1270; Tel: 319-335-3504
Leonard R MacGillivray - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA; Fax: 319-335-1270; Tel: 319-335-3504
Clifford E Berkman - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858
Paul D Benny - Department of Chemistry, Washington State University, Pullman WA 99164, USA; Fax: 509-335-8867; Tel: 509-335-3858
Publication Details: Chemical communications (Cambridge, England), Vol.47(48), pp.12846-12848
Academic Unit: Chemistry, Department of
Grant note: T32 GM008336-22 || GM / National Institute of General Medical Sciences : NIGMS T32 GM008336-21 || GM / National Institute of General Medical Sciences : NIGMS
Identifiers: 99900547289001842
Language: English
Resource Type: Journal article