Journal article
The innate immune response in calves to Boophilus microplus tick transmitted Babesia bovis involves type-1 cytokine induction and NK-like cells in the spleen
Parasite immunology, Vol.25(4), pp.185-188
04/2003
Handle:
https://hdl.handle.net/2376/115698
PMID: 12940961
Abstract
The innate immune response to Babesia bovis infection in cattle is age-related, spleen-dependent and, in stabilate inoculated calves, has type-1 characteristics, including the early induction of IL-12 and IFN-gamma. In this study with three calves, parameters of innate immunity were followed for 2 weeks after tick transmission of B. bovis. Each calf survived the acute disease episode without drug intervention, and responded with increased levels of plasma interferon-gamma and type-1 cytokine expression, monocyte/macrophage activation, and CD8+ cellular proliferation in the spleen. The proliferating CD8+ population consisted primarily of NK-like cells, and the expansion occurred in parallel with an increase in IL-15 mRNA expression in the spleen.
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Details
- Title
- The innate immune response in calves to Boophilus microplus tick transmitted Babesia bovis involves type-1 cytokine induction and NK-like cells in the spleen
- Creators
- W L Goff - Animal Disease Research Unit, USDA-ARS, Pullman, WA 99164-6630, USA. wgoff@vetmed.wsu.eduW C JohnsonR H HornG M BarringtonD P Knowles
- Publication Details
- Parasite immunology, Vol.25(4), pp.185-188
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- England
- Identifiers
- 99900548279001842
- Language
- English
- Resource Type
- Journal article