Journal article
The intraflagellar transport machinery of Chlamydomonas reinhardtii
Traffic (Copenhagen, Denmark), Vol.4(7), pp.435-442
07/2003
Handle:
https://hdl.handle.net/2376/118355
PMID: 12795688
Abstract
First discovered in the green alga, Chlamydomonas, intraflagellar transport (IFT) is the bidirectional movement of protein particles along the length of eukaryotic cilia and flagella. Composed of approximately 16 different proteins, IFT particles are moved out to the distal tip of the organelle by kinesin-II and are brought back to the cell body by cytoplasmic dynein 1b. Mutant analysis of the IFT motor and particle proteins using diverse organisms has revealed a conserved and essential role for IFT in the assembly and maintenance of cilia and flagella. IFT is thought to mediate this assembly through the delivery of axonemal precursors out to the distal tip of the growing organelle. Consistent with this model, the IFT particle proteins are rich in protein-protein binding motifs, suggesting that the particles may act as scaffolds for the binding of multiple cargoes. With most of the IFT proteins now identified at the level of the gene, this review will briefly examine both the structure and function of the IFT machinery of Chlamydomonas reinhardtii.
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Details
- Title
- The intraflagellar transport machinery of Chlamydomonas reinhardtii
- Creators
- Douglas G Cole - Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho, 83844-3052, USA. dcole@uidaho.edu
- Publication Details
- Traffic (Copenhagen, Denmark), Vol.4(7), pp.435-442
- Academic Unit
- Center for Reproductive Biology
- Publisher
- England
- Grant note
- GM61920 / NIGMS NIH HHS
- Identifiers
- 99900547915901842
- Language
- English
- Resource Type
- Journal article