The long (and winding) road to gene discovery for canine hip dysplasia

Lan Zhu; Zhiwu Zhang; Steven Friedenberg; Seung-Woo Jung; Janjira Phavaphutanon; Margaret Vernier-Singer; Elizabeth Corey; Raluca Mateescu; Nathan Dykes; Jody Sandler; Gregory Acland; George Lust; Rory Todhunter

doi:10.1016/j.tvjl.2009.02.008

Back

The long (and winding) road to gene discovery for canine hip dysplasia

Journal article

Open access

Peer reviewed

The long (and winding) road to gene discovery for canine hip dysplasia

Lan Zhu, Zhiwu Zhang, Steven Friedenberg, Seung-Woo Jung, Janjira Phavaphutanon, Margaret Vernier-Singer, Elizabeth Corey, Raluca Mateescu, Nathan Dykes, Jody Sandler, …

The veterinary journal (1997), Vol.181(2), pp.97-110

2009

DOI: https://doi.org/10.1016/j.tvjl.2009.02.008

Handle:

https://hdl.handle.net/2376/106361

PMCID: PMC2679856

PMID: 19297220

Files and links (1)

url

https://doi.org/10.1016/j.tvjl.2009.02.008View

Published (Version of record) Open

Abstract

Single nucleotide polymorphisms (SNP)

Microsatellites

Breeding values

Genome wide screen

Canine hip dysplasia

Hip dysplasia is a common inherited trait of dogs that results in secondary osteoarthritis. In this article the methods used to uncover the mutations contributing to this condition are reviewed, beginning with hip phenotyping. Coarse, genome-wide, microsatellite-based screens of pedigrees of greyhounds and dysplastic Labrador retrievers were used to identify linked quantitative trait loci (QTL). Fine-mapping across two chromosomes (CFA11 and 29) was employed using single nucleotide polymorphism (SNP) genotyping. Power analyses and preferential selection of dogs for ongoing SNP-based genotyping is described with the aim of refining the QTL intervals to 1–2 megabases on these and several additional chromosomes prior to candidate gene screening. The review considers how a mutation or a genetic marker such as a SNP or haplotype of SNPs might be combined with pedigree and phenotype information to create a ‘breeding value’ that could improve the accuracy of predicting a dog’s hip conformation.

Metrics

7 Record Views

Details

Title: The long (and winding) road to gene discovery for canine hip dysplasia
Creators: Lan Zhu - Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Zhiwu Zhang - Institute for Genomic Diversity, 175 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
Steven Friedenberg - Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Seung-Woo Jung - Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Janjira Phavaphutanon - Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Margaret Vernier-Singer - Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Elizabeth Corey - Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Raluca Mateescu - Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Nathan Dykes - Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Jody Sandler - Guiding Eyes for the Blind, Yorktown Heights, NY 10598, USA
Gregory Acland - Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
George Lust - Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Rory Todhunter - Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Publication Details: The veterinary journal (1997), Vol.181(2), pp.97-110
Academic Unit: Crop and Soil Sciences, Department of
Publisher: Elsevier Ltd
Identifiers: 99900546741001842
Language: English
Resource Type: Journal article