The mode of evolution of molecular markers in populations of house mice under artificial selection for locomotor behavior

T J Morgan; T Garland, Jr; B L Irwin; J G Swallow; P A Carter

doi:10.1093/jhered/esg021

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The mode of evolution of molecular markers in populations of house mice under artificial selection for locomotor behavior

Journal article

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The mode of evolution of molecular markers in populations of house mice under artificial selection for locomotor behavior

T J Morgan, T Garland, Jr, B L Irwin, J G Swallow and P A Carter

The Journal of heredity, Vol.94(3), pp.236-242

05/2003

DOI: https://doi.org/10.1093/jhered/esg021

Handle:

https://hdl.handle.net/2376/112634

PMID: 12816964

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Abstract

Isoenzymes - genetics

Gene Frequency

Genotype

Male

Genetic Markers

Mice, Inbred ICR

Biological Evolution

Genetic Variation

Motor Activity - genetics

Animals

Female

Mice

Microsatellite Repeats

Crosses, Genetic

A complete understanding of the mode of evolution of molecular markers is important for making inferences about different population genetic parameters, especially because a number of studies have reported patterns of allelic variation at molecular markers that are not in agreement with neutral evolutionary expectations. In the present study, house mice (Mus domesticus) from the fourteenth generation of a selection experiment for increased voluntary wheel-running activity were used to test how selection on a complex behavior affects the distribution of allelic variation by examining patterns of variation at six microsatellite and four allozyme loci. This population had a hierarchical structure that allowed for simultaneous testing of the effects of selection and genetic drift on the distribution of allelic variation by comparing observed patterns of allele frequencies and estimates of genetic divergence at multiple hierarchical levels to expectations under models of neutral evolution. The levels of genetic divergence among replicate lines and between selection groups, estimated from microsatellite data or pooled microsatellite and allozyme data, were not significantly different from expectations under neutral evolution. Furthermore, the pattern of change of allele frequencies between the base population and generation 14 was largely in agreement with expectations under neutral evolution (although the PGM locus exhibited a pattern of change within populations that was difficult to explain under neutral evolution). Overall the results generally provide support for the neutral evolution of molecular markers.

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Title: The mode of evolution of molecular markers in populations of house mice under artificial selection for locomotor behavior
Creators: T J Morgan - School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, USA. tjmorgan@unity.ncsu.edu
T Garland, Jr
B L Irwin
J G Swallow
P A Carter
Publication Details: The Journal of heredity, Vol.94(3), pp.236-242
Academic Unit: Biological Sciences, School of
Publisher: United States
Identifiers: 99900547410501842
Language: English
Resource Type: Journal article