Journal article
The mouse A/HeJ Y chromosome: Another good Y gone bad
Chromosome research, Vol.16(4), pp.623-636
06/2008
Handle:
https://hdl.handle.net/2376/107391
PMID: 18483871
Abstract
In both humans and mice there are numerous reports of Y chromosome abnormalities that interfere with sex determination. Recent studies in the mouse of one such mutation have identified Y chromosome nondisjunction during preimplantation development as the cause of abnormal testis determination that results in a high frequency of true hermaphroditism. We report here that the mouse Y chromosome from the A/HeJ inbred strain induces similar aberrations in sex determination. Our analyses provide evidence, however, that the mechanism underlying these aberrations is not Y chromosome nondisjunction. On the basis of our findings, we postulate that a mutation at or near the centromere affects both the segregation and sex-determining properties of the A/HeJ Y chromosome. This Y chromosome adds to the growing list of Y chromosome aberrations in humans and mice. In both species, the centromere of the Y is structurally and morphologically distinct from the centromeres of all other chromosomes. We conclude that these centromeric features make the human and mouse Y chromosomes extremely sensitive to minor structural alterations, and that our studies provide yet another example of a good Y chromosome gone ‘bad.’
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Details
- Title
- The mouse A/HeJ Y chromosome: Another good Y gone bad
- Creators
- Patricia Hunt - School of Molecular Biosciences, Fulmer Hall 539 Washington State University Mail drop 644660 Pullman WA 99164-4660 USAJodi Jackson - Department of Genetics Case Western Reserve University Cleveland OH 44106 USASonia Horan - School of Molecular Biosciences, Fulmer Hall 539 Washington State University Mail drop 644660 Pullman WA 99164-4660 USACrystal Lawson - School of Molecular Biosciences, Fulmer Hall 539 Washington State University Mail drop 644660 Pullman WA 99164-4660 USALaura Grindell - School of Molecular Biosciences, Fulmer Hall 539 Washington State University Mail drop 644660 Pullman WA 99164-4660 USALinda Washburn - The Jackson Laboratory Bar Harbor ME 04609 USAEva Eicher - The Jackson Laboratory Bar Harbor ME 04609 USA
- Publication Details
- Chromosome research, Vol.16(4), pp.623-636
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Springer Netherlands; Dordrecht
- Identifiers
- 99900547363701842
- Language
- English
- Resource Type
- Journal article