Journal article
The origin of human aneuploidy: where we have been, where we are going
Human molecular genetics, Vol.16 Spec No. 2(2), pp.R203-R208
10/15/2007
Handle:
https://hdl.handle.net/2376/115159
PMID: 17911163
Abstract
Aneuploidy is the most common chromosome abnormality in humans, and is the leading genetic cause of miscarriage and congenital birth defects. Since the identification of the first human aneuploid conditions nearly a half-century ago, a great deal of information has accrued on its origin and etiology. We know that most aneuploidy derives from errors in maternal meiosis I, that maternal age is a risk factor for most, if not all, human trisomies, and that alterations in recombination are an important contributor to meiotic non-disjunction. In this review, we summarize some of the data that have led to these conclusions, and discuss some of the approaches now being used to address the underlying causes of meiotic non-disjunction in humans.
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Details
- Title
- The origin of human aneuploidy: where we have been, where we are going
- Creators
- Terry Hassold - School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA. terryhassold@wsu.eduHeather HallPatricia Hunt
- Publication Details
- Human molecular genetics, Vol.16 Spec No. 2(2), pp.R203-R208
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- England
- Grant note
- HD42720 / NICHD NIH HHS HD21341 / NICHD NIH HHS ES13527 / NIEHS NIH HHS HD37502 / NICHD NIH HHS
- Identifiers
- 99900547995601842
- Language
- English
- Resource Type
- Journal article