Journal article
The origin of trisomy 22: evidence for acrocentric chromosome-specific patterns of nondisjunction
American journal of medical genetics. Part A, Vol.143A(19), pp.2249-2255
10/01/2007
Handle:
https://hdl.handle.net/2376/114613
PMID: 17705154
Abstract
Trisomy 22 is one of the most common trisomies in clinically recognized pregnancies, yet relatively little is known about the origin of nondisjunction for chromosome 22. Accordingly, we initiated studies to investigate the origin of the extra chromosome in 130 trisomy 22 cases. Our results indicate that the majority of trisomy 22 errors (>96%) arise during oogenesis with most of these errors ( approximately 90%) occurring during the first meiotic division. As with other trisomies, failure to recombine contributed to nondisjunction of chromosome 22. Taken together with data available for other trisomies, our results suggest patterns of nondisjunction that are shared among the acrocentric, but not all nonacrocentric, chromosomes.
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Details
- Title
- The origin of trisomy 22: evidence for acrocentric chromosome-specific patterns of nondisjunction
- Creators
- Heather E Hall - Center for Reproductive Biology and School of Molecular Biosciences, Washington State University, Pullman, Washington 99164-4660, USAUrvashi SurtiLori HoffnerSofia ShirleyEleanor FeingoldTerry Hassold
- Publication Details
- American journal of medical genetics. Part A, Vol.143A(19), pp.2249-2255
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- United States
- Grant note
- HD38979 / NICHD NIH HHS HD21341 / NICHD NIH HHS
- Identifiers
- 99900547829501842
- Language
- English
- Resource Type
- Journal article