Journal article
The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice
Proceedings of the National Academy of Sciences - PNAS, Vol.106(33), pp.14069-14074
08/18/2009
Handle:
https://hdl.handle.net/2376/104914
PMCID: PMC2729021
PMID: 19666521
Abstract
Peptidergic mechanisms controlling feeding, metabolism, thermoregulation, and sleep overlap in the hypothalamus. Low ambient temperatures and food restriction induce hypothermic (torpor) bouts and characteristic metabolic and sleep changes in mice. We report that mice lacking the preproghrelin gene, but not those lacking the ghrelin receptor, have impaired abilities to manifest and integrate normal sleep and thermoregulatory responses to metabolic challenges. In response to fasting at 17 °C (a subthermoneutral ambient temperature), preproghrelin knockout mice enter hypothermic bouts associated with reduced sleep, culminating in a marked drop in body temperature to near-ambient levels. Prior treatment with obestatin, another preproghrelin gene product, attenuates the hypothermic response of preproghrelin knockout mice. Results suggest that obestatin is a component in the coordinated regulation of metabolism and sleep during torpor.
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Details
- Title
- The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice
- Creators
- Éva Szentirmai - Sleep and Performance Research Center, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164Levente Kapás - Department of Biological Sciences, Fordham University, Bronx, NY 10458; andYuxiang Sun - Huffington Center on Aging, Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030Roy G Smith - Huffington Center on Aging, Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030James M Krueger - Sleep and Performance Research Center, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.106(33), pp.14069-14074
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- National Academy of Sciences
- Identifiers
- 99900546638701842
- Language
- English
- Resource Type
- Journal article