Journal article
The relA Homolog of Mycobacterium smegmatis Affects Cell Appearance, Viability, and Gene Expression
Journal of bacteriology, Vol.187(7), pp.2439-2447
04/2005
Handle:
https://hdl.handle.net/2376/110222
PMCID: PMC1065248
PMID: 15774887
Abstract
The modification of metabolic pathways to allow for a dormant lifestyle appears to be an important feature for the survival of pathogenic bacteria within their host. One regulatory mechanism for persistent
Mycobacterium tuberculosis
infections is the stringent response. In this study, we analyze the stringent response of a nonpathogenic, saprophytic mycobacterial species,
Mycobacterium smegmatis
. The use of
M. smegmatis
as a tool for studying the mycobacterial stringent response was demonstrated by measuring the expression of two
M. tuberculosis
genes,
hspX
and
eis
, in
M. smegmatis
in the presence and absence of
rel
Msm
. The stringent response plays a role in
M. smegmatis
cellular and colony formation that is suggestive of changes in the bacterial cell wall structure.
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Details
- Title
- The relA Homolog of Mycobacterium smegmatis Affects Cell Appearance, Viability, and Gene Expression
- Creators
- John L Dahl - School of Molecular Biosciences, Washington State University, Pullman, WashingtonKriti Arora - School of Molecular Biosciences, Washington State University, Pullman, WashingtonHelena I Boshoff - School of Molecular Biosciences, Washington State University, Pullman, WashingtonDanelle C Whiteford - School of Molecular Biosciences, Washington State University, Pullman, WashingtonSophia A Pacheco - School of Molecular Biosciences, Washington State University, Pullman, WashingtonOlaus J Walsh - School of Molecular Biosciences, Washington State University, Pullman, WashingtonDalia Lau-Bonilla - School of Molecular Biosciences, Washington State University, Pullman, WashingtonWilliam B Davis - School of Molecular Biosciences, Washington State University, Pullman, WashingtonAnthony G Garza - School of Molecular Biosciences, Washington State University, Pullman, Washington
- Publication Details
- Journal of bacteriology, Vol.187(7), pp.2439-2447
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- American Society for Microbiology
- Identifiers
- 99900547137801842
- Language
- English
- Resource Type
- Journal article