Journal article
The role of cytokines in sleep regulation
Current pharmaceutical design, Vol.14(32), pp.3408-3416
2008
Handle:
https://hdl.handle.net/2376/105783
PMCID: PMC2692603
PMID: 19075717
Abstract
Interleukin-1 beta (IL1) and tumor necrosis factor alpha (TNF) promote non-rapid eye movement sleep under physiological and inflammatory conditions. Additional cytokines are also likely involved but evidence is insufficient to conclude that they are sleep regulatory substances. Many of the symptoms induced by sleep loss, e.g. sleepiness, fatigue, poor cognition, enhanced sensitivity to pain, can be elicited by injection of exogenous IL1 or TNF. We propose that ATP, released during neurotransmission, acting via purine P2 receptors on glia releases IL1 and TNF. This mechanism may provide the means by which the brain keeps track of prior usage history. IL1 and TNF in turn act on neurons to change their intrinsic properties and thereby change input-output properties (i.e. state shift) of the local network involved. Direct evidence indicates that cortical columns oscillate between states, one of which shares properties with organism sleep. We conclude that sleep is a local use-dependent process influenced by cytokines and their effector molecules such as nitric oxide, prostaglandins and adenosine.
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Details
- Title
- The role of cytokines in sleep regulation
- Creators
- James M Krueger - Sleep and Performance Research Center, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6520, USA. krueger@vetmed.wsu.edu
- Publication Details
- Current pharmaceutical design, Vol.14(32), pp.3408-3416
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United Arab Emirates
- Grant note
- R01 NS027250 / NINDS NIH HHS NS25378 / NINDS NIH HHS NS31453 / NINDS NIH HHS R01 NS025378 / NINDS NIH HHS R01 NS027250-21 / NINDS NIH HHS R01 NS031453 / NINDS NIH HHS R01 HD036520 / NICHD NIH HHS HD36520 / NICHD NIH HHS R01 NS031453-15 / NINDS NIH HHS
- Identifiers
- 99900546927501842
- Language
- English
- Resource Type
- Journal article