Journal article
The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha
Brain, behavior, and immunity, Vol.18(4), pp.390-398
07/2004
Handle:
https://hdl.handle.net/2376/110833
PMID: 15157956
Abstract
It is well established that cytokines such as tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) are involved in physiological sleep regulation, yet their downstream somnogenic mechanisms remain largely uninvestigated. Nitric oxide (NO) is an effector molecule for some TNFalpha actions. Neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) gene knockout (KO) mice sleep differently than their respective controls. In this study, we tested the hypothesis that NO mediates TNFalpha-induced sleep using iNOS and nNOS KO mice and their corresponding wild-type controls. Systemic administration of TNFalpha increased non-rapid eye movement sleep (NREMS) in the two control strains and in the iNOS KO mice during the first 4 h post-injection but failed to increase NREMS in nNOS KO mice. Rapid eye movement sleep (REMS) was suppressed by TNFalpha in nNOS controls but not in the other strains examined. The results suggest that TNFalpha affects sleep, in part, through nNOS.
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Details
- Title
- The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha
- Creators
- Lichao Chen - Department of VCAPP, Washington State University, Pullman, WA 99164-6520, USAPing TaishiJeannine A MajdeZoltan PeterfiFerenc Obal, JrJames M Krueger
- Publication Details
- Brain, behavior, and immunity, Vol.18(4), pp.390-398
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Netherlands
- Grant note
- NS31453 / NINDS NIH HHS HD36520 / NICHD NIH HHS
- Identifiers
- 99900547021601842
- Language
- English
- Resource Type
- Journal article