Journal article
The sleep–wake cycle and Alzheimer’s disease: what do we know?
Neurodegenerative disease management, Vol.4(5), pp.351-362
2014
Handle:
https://hdl.handle.net/2376/104411
PMCID: PMC4257134
PMID: 25405649
Abstract
Sleep–wake disturbances are a highly prevalent and often disabling feature of Alzheimer’s disease (AD). A cardinal feature of AD includes the formation of amyloid plaques, associated with the extracellular accumulation of the amyloid-β (Aβ) peptide. Evidence from animal and human studies suggests that Aβ pathology may disrupt the sleep–wake cycle, in that as Aβ accumulates, more sleep–wake fragmentation develops. Furthermore, recent research in animal and human studies suggests that the sleep–wake cycle itself may influence Alzheimer’s disease onset and progression. Chronic sleep deprivation increases amyloid plaque deposition, and sleep extension results in fewer plaques in experimental models. In this review geared towards the practicing clinician, we discuss possible mechanisms underlying the reciprocal relationship between the sleep–wake cycle and AD pathology and behavior, and present current approaches to therapy for sleep disorders in AD.
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Details
- Title
- The sleep–wake cycle and Alzheimer’s disease: what do we know?
- Creators
- Miranda M Lim - Division of Hospital & Specialty Medicine, Sleep Disorders Laboratory, Portland Veterans Affairs Medical Center, Portland, OR 97239, USAJason R Gerstner - Center for Sleep & Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USADavid M Holtzman - Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center, Washington University, Saint Louis, MO 63110, USA
- Publication Details
- Neurodegenerative disease management, Vol.4(5), pp.351-362
- Academic Unit
- Biomedical Sciences, Department of
- Identifiers
- 99900546896201842
- Language
- English
- Resource Type
- Journal article