Journal article
The somatostatin analog, octreotide, causes accumulation of growth hormone-releasing hormone and depletion of angiotensin in the rat hypothalamus
Neuroscience letters, Vol.315(1), pp.37-40
2001
Handle:
https://hdl.handle.net/2376/103951
PMID: 11711209
Abstract
Rats were injected intracerebroventricularly with the somatostatin analog, octreotide (OCT; 0.1 μg) or vehicle, and hypothalamic contents of growth hormone-releasing hormone (GHRH), angiotensin II, and vasopressin were determined 10 min, 1, 3 and 6 h post-injection. OCT elicited an immediate release of angiotensin II (10 min) and a rise in GHRH content (1 h) followed by gradual (1–6 h) depletion of accumulated GHRH. Hypothalamic vasopressin was not altered but decreases in pituitary vasopressin occurred 10 min post-injection. The OCT-induced alterations in GHRH may explain previously reported changes in sleep whereas angiotensin may mediate OCT-induced drinking, vasopressin secretion and rises in blood pressure via sst2 somatostatin receptors.
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Details
- Title
- The somatostatin analog, octreotide, causes accumulation of growth hormone-releasing hormone and depletion of angiotensin in the rat hypothalamus
- Creators
- J Gardi - Endocrine Unit, A. Szent-Györgyi Medical Center, University of Szeged, 6720 Szeged, HungaryE Szentirmai - Department of Physiology, A. Szent-Györgyi Medical Center, University of Szeged, 6720 Szeged, HungaryI Hajdu - Department of Physiology, A. Szent-Györgyi Medical Center, University of Szeged, 6720 Szeged, HungaryF Obal - Department of Physiology, A. Szent-Györgyi Medical Center, University of Szeged, 6720 Szeged, HungaryJ.M Krueger - Department of Veterinary and Comparative Anatomy, Physiology and Pharmacology, Washington State University, P.O. Box 646520, Pullman, WA 99164-6520, USA
- Publication Details
- Neuroscience letters, Vol.315(1), pp.37-40
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900547084901842
- Language
- English
- Resource Type
- Journal article