Thiol-activated gem-dithiols: a new class of controllable hydrogen sulfide donors

Yu Zhao; Jianming Kang; Chung-Min Park; Powell E Bagdon; Bo Peng; Ming Xian

doi:10.1021/ol502088m

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Thiol-activated gem-dithiols: a new class of controllable hydrogen sulfide donors

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Thiol-activated gem-dithiols: a new class of controllable hydrogen sulfide donors

Yu Zhao, Jianming Kang, Chung-Min Park, Powell E Bagdon, Bo Peng and Ming Xian

Organic letters, Vol.16(17), pp.4536-4539

09/05/2014

DOI: https://doi.org/10.1021/ol502088m

Handle:

https://hdl.handle.net/2376/110837

PMCID: PMC4156246

PMID: 25141097

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Abstract

Toluene - analogs & derivatives

Hydrogen Sulfide - chemistry

Sulfhydryl Compounds - chemistry

Glutathione - chemistry

Molecular Structure

Cysteine - chemistry

Toluene - chemistry

A class of novel thiol-activated H2S donors has been developed on the basis of the gem-dithiol template. These donors release H2S in the presence of cysteine or GSH in aqueous solutions as well as in cellular environments.

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Title: Thiol-activated gem-dithiols: a new class of controllable hydrogen sulfide donors
Creators: Yu Zhao - Department of Chemistry, Washington State University , Pullman, Washington 99164, United States
Jianming Kang
Chung-Min Park
Powell E Bagdon
Bo Peng
Ming Xian
Publication Details: Organic letters, Vol.16(17), pp.4536-4539
Academic Unit: Chemistry, Department of
Publisher: United States
Grant note: R01 HL116571 / NHLBI NIH HHS R01HL116571 / NHLBI NIH HHS
Identifiers: 99900547291801842
Language: English
Resource Type: Journal article