Journal article
Time of day differences in IL1β and TNFα mRNA levels in specific regions of the rat brain
Neuroscience letters, Vol.352(1), pp.61-63
2003
Handle:
https://hdl.handle.net/2376/116724
PMID: 14615050
Abstract
Interleukin-1β (IL1β) and tumor necrosis factor-α (TNFα) are involved in several physiological functions regulated by brain. The current studies were performed to determine whether a diurnal rhythm of IL1β and TNFα mRNAs, determined by real time RT-PCR, existed in specific brain regions linked to the functions of these cytokines. Rats were sacrificed 2 h after light onset (AM) and 1 h prior to dark onset (PM). IL1β mRNA levels in the AM were significantly higher than those obtained from rats sacrificed in the PM in the prefrontal cortex, parietal cortex, amygdala/piriform cortex, ventral hippocampus, hypothalamus, nucleus tractus solitarius, and nucleus accumbens, but not in the dorsal hippocampus. Time-of-day differences in TNFα mRNA levels were observed in all these brain regions. These results support the hypothesis that TNFα and IL1β have physiological roles within the brain.
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Details
- Title
- Time of day differences in IL1β and TNFα mRNA levels in specific regions of the rat brain
- Creators
- Cassia CearleyLynn ChurchillJames M Krueger
- Publication Details
- Neuroscience letters, Vol.352(1), pp.61-63
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900547465701842
- Language
- English
- Resource Type
- Journal article