Journal article
Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies
American journal of epidemiology, Vol.170(8), pp.937-947
2009
Handle:
https://hdl.handle.net/2376/106772
PMCID: PMC2800266
PMID: 19745021
Abstract
Although cigarette smoking and alcohol consumption increase risk for head and neck cancers, there have been few attempts to model risks quantitatively and to formally evaluate cancer site-specific risks. The authors pooled data from 15 case-control studies and modeled the excess odds ratio (EOR) to assess risk by total exposure (pack-years and drink-years) and its modification by exposure rate (cigarettes/day and drinks/day). The smoking analysis included 1,761 laryngeal, 2,453 pharyngeal, and 1,990 oral cavity cancers, and the alcohol analysis included 2,551 laryngeal, 3,693 pharyngeal, and 3,116 oval cavity cancers, with over 8,000 controls. Above 15 cigarettes/day, the EOR/pack-year decreased with increasing cigarettes/day, suggesting that greater cigarettes/day for a shorter duration was less deleterious than fewer cigarettes/day for a longer duration. Estimates of EOR/pack-year were homogeneous across sites, while the effects of cigarettes/day varied, indicating that the greater laryngeal cancer risk derived from differential cigarettes/day effects and not pack-years. EOR/drink-year estimates increased through 10 drinks/day, suggesting that greater drinks/day for a shorter duration was more deleterious than fewer drinks/day for a longer duration. Above 10 drinks/day, data were limited. EOR/drink-year estimates varied by site, while drinks/day effects were homogeneous, indicating that the greater pharyngeal/oral cavity cancer risk with alcohol consumption derived from the differential effects of drink-years and not drinks/day.
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Details
- Title
- Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies
- Creators
- Jay H LUBIN - National Cancer Institute, Bethesda, Maryland, United StatesMark PURDUE - National Cancer Institute, Bethesda, Maryland, United StatesOxana SHANGINA - Cancer Research Centre, Moscow, Russian FederationStephen M SCHWARTZ - Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesPeter RUDNAI - National Institute of Environmental Health, Budapest, HungaryJose ELUF NETO - Universidade de Sao Paulo, Sao Paulo, BrazilJoshua MUSCAT - College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, United StatesHal MORGENSTERN - Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, United StatesAna MENEZES - Universidade Federal de Pelotas, Pelotas, BrazilElena MATOS - Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, ArgentinaLoan NICOLAE MATES - University of Medicine and Pharmacy Carol Davila, Bucharest, RomaniaJolanta LISSOWSKA - M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Prevention, Warsaw, PolandKarl KELSEY - Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, United StatesFabio LEVI - Institut de médecine sociale et preventive, Université de Lausanne, Lausanne, SwitzerlandPhilip LAZARUS - College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, United StatesCarlo LA VECCHIA - Istituto di Ricerche Farmacologiche Mario Negri and University of Milan, Milan, ItalySergio KOIFMAN - Escola Nacional de Saude Publica, Fundaçao Oswaldo Cruz, Rio de Janeiro, BrazilRolando HERRERO - Instituto de Investigación Epidemiológica, San José, Costa RicaSilvia FRANCESCHI - International Agency for Research on Cancer, Lyon, FranceVictor WÜNSCH-FILHO - Universidade de Sao Paulo, Sao Paulo, BrazilLeticia FERNANDEZ - Institute of Oncology and Radiobiology, Havana, CubaEleonora FABIANOVA - Specialized State Health Institute, Banská Bystrica, SlovakiaAlexander W DAUDT - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilZuo-Feng ZHANG - School of Public Health, University of California, Los Angeles, California, United StatesLuigino DAL MASO - Aviano Cancer Centre, Aviano, ItalyMaria Paula CURADO - International Agency for Research on Cancer, Lyon, FranceCHU CHU CHEN - Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesXavier CASTELLSAGUE - Institut Català d'Oncologia (ICO), IDIBELL, CIBER-ESP, L'Hospitalet de Llobregat, Barcelona, SpainPaul BRENNAN - International Agency for Research on Cancer, Lyon, FrancePaolo BOFFETTA - International Agency for Research on Cancer, Lyon, FranceMia HASHIBE - International Agency for Research on Cancer, Lyon, FranceRichard B HAYES - National Cancer Institute, Bethesda, Maryland, United StatesDebbie WINN - National Cancer Institute, Bethesda, Maryland, United StatesQINGYI QINGYI WEI - University of Texas-M. D. Anderson Cancer Center, Houston, Texas, United StatesRenato TALAMINI - Aviano Cancer Centre, Aviano, ItalyNeonilia SZESZENIA-DABROWSKA - Institute of Occupational Medicine, Lodz, PolandErich M STURGIS - University of Texas-M. D. Anderson Cancer Center, Houston, Texas, United StatesElaine SMITH - College of Public Health, University of Iowa, Iowa City, Iowa, United States
- Publication Details
- American journal of epidemiology, Vol.170(8), pp.937-947
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- Oxford University Press; Cary, NC
- Number of pages
- 11
- Grant note
- Department of Health and Human Services T32CA009142; ZIACP010183 / National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Intramural Research Program of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Identifiers
- 99900546933901842
- Language
- Russian
- Resource Type
- Journal article