Journal article
Transforming growth factor beta (TGFβ1, TGFβ2 and TGFβ3) null-mutant phenotypes in embryonic gonadal development
Molecular and cellular endocrinology, Vol.294(1), pp.70-80
2008
Handle:
https://hdl.handle.net/2376/105761
PMCID: PMC2593935
PMID: 18790002
Abstract
The role transforming growth factor beta (TGFb) isoforms TGFb1, TGFb2 and TGFb3 have in the regulation of embryonic gonadal development was investigated with the use of null-mutant (i.e. knockout) mice for each of the TGFb isoforms. Late embryonic gonadal development was investigated because homozygote TGFb null-mutant mice generally die around birth, with some embryonic loss as well. In the testis, the TGFb1 null-mutant mice had a decrease in the number of germ cells at birth, postnatal day 0 (P0). In the testis, the TGFb2 null-mutant mice had a decrease in the number of seminiferous cords at embryonic day 15 (E15). In the ovary, the TGFb2 null-mutant mice had an increase in the number of germ cells at P0. TGFb isoforms appear to have a role in gonadal development, but interactions between the isoforms is speculated to compensate in the different TGFb isoform null-mutant mice.
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Details
- Title
- Transforming growth factor beta (TGFβ1, TGFβ2 and TGFβ3) null-mutant phenotypes in embryonic gonadal development
- Creators
- Mushtaq A Memon - Center for Reproductive Biology, Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164-4234, United StatesMatthew D Anway - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234, United StatesTrevor R Covert - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234, United StatesMehmet Uzumcu - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234, United StatesMichael K Skinner - Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234, United States
- Publication Details
- Molecular and cellular endocrinology, Vol.294(1), pp.70-80
- Academic Unit
- Biological Sciences, School of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900546544401842
- Language
- English
- Resource Type
- Journal article