Transgenerational disease specific epigenetic sperm biomarkers after ancestral exposure to dioxin

Millissia Ben Maamar; Eric Nilsson; Jennifer L M Thorson; Daniel Beck; Michael K Skinner

doi:10.1016/j.envres.2020.110279

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Transgenerational disease specific epigenetic sperm biomarkers after ancestral exposure to dioxin

Journal article

Open access

Peer reviewed

Transgenerational disease specific epigenetic sperm biomarkers after ancestral exposure to dioxin

Millissia Ben Maamar, Eric Nilsson, Jennifer L M Thorson, Daniel Beck and Michael K Skinner

Environmental research, Vol.192, pp.110279-110279

01/01/2021

DOI: https://doi.org/10.1016/j.envres.2020.110279

PMCID: PMC8130889

PMID: 33039529

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Abstract

Biomarkers - metabolism

Dioxins - toxicity

DNA Methylation

Epigenesis, Genetic

Polychlorinated Dibenzodioxins

Rats, Sprague-Dawley

Sexual Maturation

Spermatozoa - metabolism

Dioxin was historically one of the most common industrial contaminants with several major industry accidents, as well as governmental actions involving military service, having exposed large numbers of the worldwide population over the past century. Previous rat studies have demonstrated the ability of dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)) exposure to promote the epigenetic transgenerational inheritance of disease susceptibility in subsequent generations. The types of disease previously observed include puberty abnormalities, testis, ovary, kidney, prostate and obesity pathologies. The current study was designed to use an epigenome-wide association study (EWAS) to identify potential sperm DNA methylation biomarkers for specific transgenerational diseases. Therefore, the transgenerational F3 generation dioxin lineage male rats with and without a specific disease were compared to identify differential DNA methylation regions (DMRs) as biomarkers for disease. The genomic features of the disease-specific DMRs were characterized. Observations demonstrate that disease-specific epimutation DMRs exist for the transgenerational dioxin lineage rats that can potentially be used as epigenetic biomarkers for testis, kidney, prostate and obesity diseases. These disease-specific DMRs were associated with genes that have previously been shown to be linked with the specific diseases. This EWAS for transgenerational disease identified potential epigenetic biomarkers and provides the proof of concept of the potential to develop similar biomarkers for humans to diagnose disease susceptibilities and facilitate preventative medicine.

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Title: Transgenerational disease specific epigenetic sperm biomarkers after ancestral exposure to dioxin
Creators: Millissia Ben Maamar - Washington State University
Eric Nilsson - Washington State University
Jennifer L M Thorson - Washington State University
Daniel Beck - Washington State University
Michael K Skinner - Washington State University
Publication Details: Environmental research, Vol.192, pp.110279-110279
Academic Unit: Biological Sciences, School of
Grant note: R01 ES012974 / NIEHS NIH HHS
Identifiers: 99901080814701842
Language: English
Resource Type: Journal article