Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis

T C McGuire; D P Knowles; W C Davis; A L Brassfield; T A Stem; W P Cheevers

doi:10.1128/jvi.66.5.3247-3250.1992

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Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis

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Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis

T C McGuire, D P Knowles, W C Davis, A L Brassfield, T A Stem and W P Cheevers

Journal of virology, Vol.66(5), pp.3247-3250

05/1992

DOI: https://doi.org/10.1128/jvi.66.5.3247-3250.1992

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https://hdl.handle.net/2376/108410

PMCID: PMC241096

PMID: 1313930

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https://doi.org/10.1128/jvi.66.5.3247-3250.1992View

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Abstract

To dissect mechanisms of caprine arthritis-encephalitis lentivirus-induced arthritis, an undefined immunodominant viral glycoprotein, gp90 (G. C. Johnson, A. F. Barbet, P. Klevjer-Anderson, and T. C. McGuire, Infect. Immun. 41:657-665, 1983), was characterized. Monoclonal antibody to gp90 and specific antiserum to env gene products demonstrated that gp90 was a transmembrane protein (TM) dimer. Goats with progressive arthritis had high antibody titers to oligomeric and monomeric (38-kDa) TM.

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Title: Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis
Creators: T C McGuire - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040
D P Knowles - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040
W C Davis - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040
A L Brassfield - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040
T A Stem - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040
W P Cheevers - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040
Publication Details: Journal of virology, Vol.66(5), pp.3247-3250
Academic Unit: Veterinary Microbiology and Pathology, Department of
Identifiers: 99900547447701842
Language: English
Resource Type: Journal article