Journal article
Transmission-dynamic model to capture the indirect effects of infant vaccination with Prevnar (7-valent pneumococcal conjugate vaccine (PCV7)) in older populations
Vaccine, Vol.27(34), pp.4694-4703
2009
Handle:
https://hdl.handle.net/2376/102671
PMID: 19520197
Abstract
We developed an age-structured, transmission-dynamic, mathematical model to quantify the direct and indirect benefits of infant PCV7 vaccination. The model simulates the acquisition of asymptomatic carriage of
Streptococcus pneumoniae and the development of fatal and non-fatal invasive pneumococcal disease (IPD) among vaccinated and unvaccinated individuals aged <2, 2–4, 5–17, 18–49, 50–64, and ≥65 years old. The model was parameterized using published US surveillance data, supplemented with data from published literature. The model predicts the observed incidence of IPD with good agreement and may be used to predict the impact of various vaccination strategies in the US or other populations yet to introduce PCV7.
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Details
- Title
- Transmission-dynamic model to capture the indirect effects of infant vaccination with Prevnar (7-valent pneumococcal conjugate vaccine (PCV7)) in older populations
- Creators
- Sonya J Snedecor - Pharmerit North America, Bethesda, MD, United StatesDavid R Strutton - Wyeth Research, Collegeville, PA, United StatesVincent Ciuryla - Wyeth Research, Collegeville, PA, United StatesElissa J Schwartz - Washington State University, Pullman, WA, United StatesMarc F Botteman - Pharmerit North America, Bethesda, MD, United States
- Publication Details
- Vaccine, Vol.27(34), pp.4694-4703
- Academic Unit
- Biological Sciences, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546529701842
- Language
- English
- Resource Type
- Journal article