Journal article
Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD
Experimental brain research, Vol.232(5), pp.1575-1584
05/2014
Handle:
https://hdl.handle.net/2376/116287
PMID: 24623353
Abstract
Post-traumatic stress disorder (PTSD) is characterized by intrusive memories of a traumatic event, avoidance behavior related to cues of the trauma, emotional numbing, and hyper-arousal. Sleep abnormalities and nightmares are core symptoms of this disorder. In this review, we propose a model which implicates abnormal activity in the locus coeruleus (LC), an important modifier of sleep–wake regulation, as the source of sleep abnormalities and memory abnormalities seen in PTSD. Abnormal LC activity may be playing a key role in symptom formation in PTSD via sleep dysregulation and suppression of hippocampal bidirectional plasticity.
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Details
- Title
- Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD
- Creators
- William Vanderheyden - University of Michigan Ann Arbor MI USAGina Poe - University of Michigan Ann Arbor MI USAIsrael Liberzon - University of Michigan Ann Arbor MI USA
- Contributors
- María Corsi Cabrera (Editor)Gina Rochelle Poe (Editor)
- Publication Details
- Experimental brain research, Vol.232(5), pp.1575-1584
- Academic Unit
- Department of Biomedical Sciences
- Publisher
- Springer Berlin Heidelberg; Berlin/Heidelberg
- Identifiers
- 99900547419801842
- Language
- English
- Resource Type
- Journal article